GHS Classification Result (Revision of the past classification result)

Chemical Name:Tetramethyl succinonitrile
CAS:3333-52-6

Result:
ID: 22B4517
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data measured by prescribed methods are available though it is reported as combustible.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine in the molecule
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 30 mg/kg (ACGIH (2001)), the substance was classified into Category 2.
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data were available. Although the rabbit LDLo value of 79.4 mg/kg was documented as the datum obtained from the "List 3" information source designated in the GHS classification guidance for the Japanese government (RTECS (2008)), the category could not be specified. Therefore, the classification was not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
According to the description that the rat minimum lethal concentration for 4-hour exposure was 0.235 mg/L and the lethal concentration by 2 to 3-hour exposure was 60 ppm (0.341 mg/L) (ACGIH (2002)), the 4-hour LC50 value was estimated to be 0.235 mg/L or more and below 0.341 mg/L. Thus, the substance was classified as Category 2. Since the toxicity value (0.235 mg/L) was higher than the saturated vapor pressure concentration (0.0084 mg/L), it was judged as dust.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (NTP DB (Access on Sep. 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the single parenteral administration study in hamsters during the organogenetic period, clonic-tonic convulsions was observed at 10 mg/kg, and deaths of dams (37%), reductions in fetal crown-rump length and increase in number of litters with exencephalia were observed at 20 mg/kg (ACGIH (2001)). However, these findings were observed only at the high dose level that severe toxic effects such as maternal death were observed, therefore, it was not adopted for grounds for classification. On the other hand, however, since no data were available on the effects of the substance on the sexual functions and fertility of parental animals that were exposed prior to mating. Therefore, the substance was classified as "Classification not possible" due to insufficient data available.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
As for the information provided from "List 2" information source designated in the GHS classification guidance for the Japanese government, there were five cases of unconsciousness with convulsion caused by acute accidental occupational exposure (HSDB (2009)). Moreover, toxicity to the central nervous system that could result in convulsions and coma was taken into consideration in the TLV-TWA recommendation for the substance (ACGIH (2001)). Based on the information, the substance was classified as Category 2 (central nervous system). In addition, occurrence of violent convulsions following exposure was also reported in the animal studies (ACGIH (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the sixteen workers who engaged in making vinyl products and were exposed to the substance, clinical signs occurred included headache, nausea, convulsions, and coma. Actually, 12 cases of headaches and 5 cases of convulsions were reported, respectively (ACGIH (2001)). Moreover, in combination with a description stating that toxicity to the central nervous system resulting in convulsions and coma was taken into consideration in the TLV-TWA recommendation for the substance (ACGIH (2001)), the substance was classified as Category 1 (central nervous system). In addition, in the 90-day oral dose toxicity study in rats (0.001 - 10 mg/kg/day) in which the test doses were low, the effects on the liver was limited to increase in its weight and any other significant effects were not observed (HSDB (2009)). The only treatment-related morphological changes in the kidney of male rats mainly consisted of degeneration of proximal tubules and hyaline droplet formation (HSDB (2009)), which were not observed in female rats and dogs. Thus, the changes were considered to be nephropathy attributed to alpha-2-microglobulin which was specific to male rats, and were not evidenced to classify.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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