GHS Classification Result （Revision of the past classification result）

Chemical Name：tetrachloronaphthalene
CAS：1335-88-2

Result：
ID: 22B4515
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available. As relevant information, it is reported as flammable (ICSC (J) (2001)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since it is reported that the substance has no autoignition temperature up to boiling point (311.5 - 360 degC) (HSDB (2006)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing chlorine (but not oxygen or fluorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- Stricture in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - The guinea pig LD50 value of > 3 mg/kg was reported (CICAD 34 (2001)). Since the value did not provide the basis for classification, the classification was not possible due to lack of sufficient data.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - The classification was not possible because specific data about the substance were not provided. As relevant information, in the human test that applied 50% of mixed preparation as mineral oil suspension containing the substance to the ear of three volunteers for 30 days, no irritation effect containing acne was observed (Assessment report in Holland (2000)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (CICAD 34 (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In exposures to polychlorinated naphthalenes or their mixtures, the effects on the skin and the liver were characteristic, and there were numerous reports regarding those effects (CICAD 34 (2001), ACGIH (2001), DFGMAK-Doc. 13 (1999)). It was also described that the higher chlorinated congeners appeared to be more toxic than the lower chlorinated ones (CICAD 34 (2001), ACGIH (2001)). As for the skin effects, there were reports describing chloracne induced after exposures to higher chlorinated congeners more than trichloronaphthalene (CICAD 34 (2001)), and for acneform eruption with pustules, papules and comedones caused by occupational exposures to trichloronaphthalene and tetrachloronaphthalene (HSDB (2009)), and chloracne observed in workers exposed to the mixture of tetra- and pentachloronaphthalene (HSDB (2009)). Thus, the substance was classified as Category 1(skin). While as for the liver effects, in the case report, there were descriptions of hepatitis accompanied by the clinical signs such as jaundice, anorexia, nausea, and vomiting, induced by occupational exposure to trichloronaphthalene, and the possible presence of tetrachloronaphthalene in the air of the workplace (ACGIH (2001)). And it was reported that systemic effects resulting in liver disease were noted by inhalation of the fumes of polychlorinated naphthalene (CICAD 34 (2001)). Based on the information, the substance was classified as Category 1(liver). In conclusion, the classification was guided to Category 1 (liver, skin).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information