GHS Classification Result （Revision of the past classification result）

Chemical Name：dioxathion
CAS：78-34-2

Result：
ID: 22B4512
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Not combustible (ICSC (1998), Sax (11th, 2004), HSDB (2005)).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Not combustible (ICSC (1998), Sax (11th, 2004), HSDB (2005))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (1998), Sax (11th, 2004), HSDB (2005))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although the substance contains a metalloid (P), the water solubility data 1.55 mg/L (25 degC estimation value) (Howard (1997)) is obtained, therefore it is considered that it does not react vigorously with water.
13 Oxidizing liquids Classification not possible - - - - Classification is not possible since no data are available though the substance contains oxygen which is bonded to phosphorus.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Not data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values of 43 mg/kg (male) and 23 mg/kg (female) (ACGIH (2002)), the substance was classified into Category 2.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For rats, Category 2 was adopted based on the LD50 values of 235 mg/kg (male) and 63 mg/kg (female) (ACGIH (2002)), by selecting the female datum with greater hazard. For rabbit, based on the LD50 value of 85 mg/kg (ACGIH (2002) and PATTY, 5th (2001)), Category 2 was adopted. From the data for both species, the substance was classified as Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 1.398 mg/L/1h (= 0.349 mg/L/4hrs) (ACGIH (2002)), the substance was classified as Category 2. The LC50 value (1.398 mg/L) was higher than the saturated vapor pressure concentration (2.15E-06 mg/L), the criterion values for dust/mist were adopted.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The substance was classified as Category 2B based on the document that the substance caused mild and transient conjunctivitis, but no corneal damage (ACGIH (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, positive results in the Ames test (NTP DB (2005)), negative results in the gene mutation test using mouse lymphoma and the chromosome aberration test using CHO cells (NTP DB (2005)) were reported.
6 Carcinogenicity Classification not possible - - - - It was classified as "Classification not possible" based on the criterion of "A4" in the carcinogenicity assessment of the ACGIH (ACGIH (2002)). As relevant information, in the examination after 33 weeks observation periods in rats and after 12-13 weeks observation periods in mice following 78-week dietary administration, no incidence of rare tumors and no changes in the incidence of tumors with statistical significance were observed, suggesting that this substance had no carcinogenicity under the test conditions (NTP TR 125 (1978)).
7 Reproductive toxicity Classification not possible - - - - In the three-generation reproductive study in rats, no adverse effect on reproductive performance, fertility, lactation or litter size was found. The progeny was viable, normal in size and anatomical structure. Findings among all test animals, in each generation, were comparable to the control animals for all parameters (JMPR 125 (1968)). However, since the data about the development of the offspring containing teratogenic effects in the examination before parturition were insufficient, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There was case report stating that a five-year-old boy who accidentally ingested the formulation containing 21% of the substance caused vomiting and diarrhea, followed by mental dullness and astasia, thereafter he revealed shallow rapid respirations, muscle fasciculation, lachrymation and miosis (ACGIH (2002)). It was also reported that oral intake of the substance in quantities greater than 0.075 mg/kg produced measurable cholinesterase inhibition in humans (NTP TR 125 (1978)). Based on the information, the substance was classified as Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 2-week oral dose study in dogs, symptoms such as hypersalivation, tremors and ataxia occurred at 8 mg/kg/day. At the dose levels of 0.8 mg/kg/day and above significant inhibition of plasma cholinesterase was observed, and at the dose levels of 2.5 and 8.0 mg/kg/day significant inhibition of red blood cell (RBC) cholinesterase was observed (ACGIH (2002)). It was also reported in the 13-week feeding study in rats that although only the females fed 100 ppm showed minimum symptoms of parasympathetic stimulation, marked brain, plasma and erythrocyte cholinesterase depression occurred in both sexes (JMPR 125 (1968)). As described above, since the effects on nervous system were observed at the dose levels corresponding to Category 1 of the guidance values, the substance was classified as Category 1 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 48h-EC50 = 0.35 microg/L for crustacea (Daphnia magna) (HSDB 2009, etc.).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (BIOWIN).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information