GHS Classification Result (Revision of the past classification result)

Chemical Name:calcium cyanide
CAS:592-01-8

Result:
ID: 22B4510
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC(1998), NFPA (13th, 2002), Weiss (2nd, 1985))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (ICSC(1998), NFPA (13th, 2002), Weiss (2nd, 1985))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(1998), NFPA (13th, 2002), Weiss (2nd, 1985))
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Classification is not possible since no detailed data are available though it is known that this substance reacts vigorously with water and emits flammable and toxic hydrogen cyanide gas.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen or halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 39 mg/kg (Recommendations for allowable concentrations, Journal of Occupational Health No. 43 (2001)), the substance was classified as Category 2.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant information, it was reported in the human case that the substance caused skin reddening and irritation (ICSC (J) (1998)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
No information about the substance was provided. As for the local effects of cyanides on the eye, conjunctival hyperemia with moderate chemosis, lachrymation, photophobia, and tingling sensation were reported (CICADs 61 (2004)). Based on the information, the substance was classified as Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, cardiovascular system), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system, cardiovascular system)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There were no data for the substance concerned, however, it was described that the primary effects of acute cyanide exposure were adverse effects on the central nervous system and on the cardiovascular system (ATSDR (2006), CICADs 61 (2004)). As for acute symptoms of cyanides, tachypnea, headache, vertigo, weak pulse, cardiac arrhythmias, vomiting, stupor, convulsions, coma were described (CICADs 61 (2004)). Moreover, it was reported that the most significant effects of cyanide exposure occurred in the nervous system, especially in the brain, and that acute inhalation of high concentrations of cyanides provoked brief central nervous stimulation followed by depression, convulsions, coma, and deaths (ATSDR (2006)). Based on the information on humans, the substance was classified as Category 1 (central nervous system, cardiovascular system). Furthermore, based on the description stating that acute inhalation exposure to cyanides had the potential for irritation and injury to the respiratory tract (ACGIH (2001)), the substance was additionally classified as Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, thyroid) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, thyroid) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
There were no data for the substance concerned, however, it was described that chronic occupational exposure to cyanide at lower concentrations caused a variety of symptoms related to the effects on the central nervous system such as fatigue, dizziness, headaches, paresthesia of extremities, syncope, hemiparesis and hemianopia (CICADs(J) 61(2004), ATSDR (2006)). In addition, behavioral changes were reported following prolonged cyanide exposure, and loss of memory and decreases in visual activity and psychomotor ability, etc. were reported in workers (ATSDR (2006)). Based on the information, the substance was classified as Category 1 (central nervous system). It was also described that thiocyanate, a main metabolite of cyanide, interfered with iodine uptake in the thyroid gland, and that reduced thyroid hormone levels followed by elevated levels of thyroid stimulating hormone, which resulted in thyroid toxicity (ATSDR (2006), CICADs (J) 61 (2004)). Enlargement of the thyroid gland and increased levels of thyroid stimulation hormone (ATSDR (2006)) and dysfunction of the thyroid gland and/or goiter (CICADs (J) 61 (2004)) were reported in workers exposed occupationally, respectively. Based on the information, the substance was classified as Category 1 (thyroid).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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