GHS Classification Result （Revision of the past classification result）

Chemical Name：Lead, tetraethyl-
CAS：78-00-2

Result：
ID: 22B4509
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point is 93 degC (closed-cup) (ATSDR (2007)), the substance is classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition temperature of 110 degC or more (ICSC (J) (2003)) was obtained and it is considered that the substance does not ignite at room temperature, therefore the substance is classified as "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although the substance contains a metal (Pb) in the molecule, the water solubility data 0.29 mg/L (HSDB (2005)) is obtained. Therefore it is considered that it does not react vigorously with water.
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine in the molecule
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Three LD50 values of 35.0 mg/kg, 14 - 17 mg/kg (ACGIH (2001)) and 1.2 mg/kg (PIMs (1994)) for rats were reported. One of them corresponded to Category 1, and the other two corresponded to Category 2. The substance was classified as Category 2, since the majority of obtained data corresponded to it.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Two LD50 values of 700 mg/kg (ACGIH (2001)) and 990 mg/kg (DFGMAK-Doc. 15 (2001)) for rabbits were reported. The substance was classified as Category 3, since all of them corresponded to the Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 0.85 mg/L/1hｒ (= 64.26 ppmV/1hr = 32.13 ppmV/4hrs) (ACGIH (2001)), the substance was classified as Category 1. The LC50 value was lower than 90% of the saturated vapor pressure concentration (513 ppmV), it was judged as "vapor hardly coexisting mist" and the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data were available. As relevant information, it is reported that the alkyl lead compounds are easily absorbed to skin and caused itch, burn and transient reddening (PIMs (1994)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The substance was classified as "Not classified" based on the negative results in the dominant lethal test using mice orally and intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells) (DFGMAK-Doc. 15 (2001)). As relevant information, as for in vitro study, negative results in the Ames test were reported (NTP DB (Access on Jun. 2009)).
6 Carcinogenicity Classification not possible - - - - It was classified as "Classification not possible" in accordance with the revision of the GHS guidance, based on the criteria of "Group 3" in the carcinogenicity assessment of the IARC (IARC suppl. 7 (1987)) and "A4" in the ACGIH (ACGIH (2001)). As relevant information, increase in the incidence of malignant lymphomas was found only in females surviving for 36 weeks after subcutaneous administration to mice through the lactation period from the birth (IARC 23 (1980)). In the human case-control study, a strong association between the occupational exposure and rectal cancer were found in workers involved in manufacturing this substance (PATTY, 5th (2001)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the gavage tests during the organogenetic period in rats or mice, increased resorption and decreased number of fetuses were observed in both species at the dose levels that general toxic effects such as decreased body weight gain, tremor, and convulsions were observed in dams. In the oral administration study in rats administered on day 9 - 11 of gestation, or day 12 - 14 of gestation, increased resorption was observed (DFGMAK-Doc.15 (2001)). Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was reported that when the substance was first introduced as a gasoline additive, more than 300 workers engaged in its production developed acute neurological symptoms and 5 died (PATTY, 5th (2001)). It was also reported that the brain was the critical organ for toxicity of the substance, and that early symptom following exposure such as nausea, vomiting and diarrhea were associated with nervous system complaints of irritability, headache, and restlessness, and might progress rapidly to severe signs of toxicity of the central nervous system containing convulsions and coma (PATTY, 5th (2001)). Based on the information, the substance was classified as Category 1 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the autopsy of the dead person who inhaled leaded gasoline, edema in the brain, necrosis of nerve cells in the hippocampus, loss of Purkinje's cells in the cerebellum and demyelination of the Varolius' pons were reported (DFGMAK-Doc.15 (2001)). Moreover, it was reported that chronic heavy abuse of sniffing of leaded gasoline might cause encephalopathy, cerebellar and corticospinal symptoms, signs of dementia, alterations in mental status, and persistent organic psychosis (PATTY, 5th (2001)). While in the 90-day oral dose study in rats, ultrastructural alterations in Schwann's cell and in unmyelinated axons were observed at the dose level of 0.2 mg/kg or more (ACGIH (2001)). In the 20-week oral (gavage) study in rats, swelling and cytoplasmic degeneration of the liver and neuronal damage were reported at the dose levels of 0.0017 - 0.17 mg/kg (IRIS (2002)). Further, in the 14-day oral dose study in mice, neurotoxic signs characterized by tremors and slight chronic hepatitis were reported at the dose level of 2.0 mg/kg (NTP Report No. IMM20009). As described above, since the effects on central nervous system and liver were evident and since the dose range were equivalent to Category 1 of the guidance values, the substance was classified as Category 1 (central nervous system, liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 96h-LC50 = 0.02 mg/L for fish (Lepomis macrochirus) (EHC85, 1989).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water and bioaccumulation potential are unknown from which it is a metal compound.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information