NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：chloroacetaldehyde
CAS：107-20-0

Result：


ID:	22B4506
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Since its flash point 190 degF (87.7 degC) (closed-cup) (Sax (11th, 2004), HSDB (2009)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive and self-reactive properties. As relevant notes, it is reported that the pure substance may polymerize when it is left standing (Merck (14th, 2006)).
9	Pyrophoric liquids	Not classified	-	-	-	-	Since its autoignition temperature is reported 88 degC (HSDB (2009)), it was judged that the substance does not ignite at room temperature.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance is an organic compound containing chlorine and oxygen which are chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Six LD50 values for rats of 23 mg/kg (ACGIH (2001)), 89 mg/kg (PATTY, 5th (2001)), 110.5 mg/kg, 127.5 mg/kg, 133 mg/kg and 98 mg/kg (the above four were from DFGMAK-Doc. 12 (1999)) were reported. One of them corresponded to Category 2, and the other five corresponded to Category 3. The substance was classified as Category 3, as the most of the data corresponded to it.
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Three LD50 values of 67 mg/kg (ACGIH (2001)), 267 mg/kg (PATTY, 5th (2001)) and 330.2 mg/kg (DFGMAK-Doc.12 (1999)) for rabbits were reported. One of them corresponded to Category 2, and the other two corresponded to Category 3. Since the number of the corresponding value was larger, the substance was classified as Category 3. For rats, two LD50 values of 140 mg/kg and 129 mg/kg (both from DFGMAK-Doc. 12 (1999)) were reported and they corresponded to Category 2. Therefore, the substance was classified as Category 2. From the results mentioned above, based on the rat data with greater hazard, the substance was classified as Category 2.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The rat LC50 values of 202.5 ppmV/1h (103 ppmV/4hrs) (PATTY, 5th (2001)), 202.5 - 243 ppmV/1h (103 - 121 ppmV/4hrs), < 25 ppmV/7hrs (< 33 ppmV/4hrs), < 50 ppmV/3.5hrs (< 46.7 ppmV/4hrs) and < 100 ppmV/2hrs (< 70.7 ppmV/4hrs) (the above four are from (DFGMAK-Doc. 12 (1999)) were reported. Two of them corresponded to Category 2, and the other three corresponded to Category 1. The substance was classified as Category 1, since the majority of obtaining data corresponded to it. As the LC50 value was lower than 90% of the saturated vapor pressure concentration (84605 ppmV), it was judged as "vapor hardly coexisting mists" and the criterion values for gas were adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 1		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was classified as "C; R34" in the EU classification (EU-Annex I (Access on Jun. 2009)).
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	In the rabbit test, instillation of 30% aqueous solution of the substance to the eyes caused severe damage (ACGIH (2001)). In human cases, 40% aqueous solution poured into eyes caused the serious hazard of injury, containing tissue destruction (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was noted as corrosive to skin.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	In the guinea pig maximization test (Magnusson-Kligman test), the non-irritating concentration of 0.002% of the substance did not cause skin sensitization (DFGMAK-Doc.12 (1999)). However, since details of test results such as positive rate and conclusion of sensitization were not provided, the classification was not possible.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	This substance is a bifunctional alkylating metabolite produced by metabolism of vinyl chloride, and it is considered to be the ultimate carcinogenic form. Considering the characteristics of the substance and similarity with acetaldehyde, possibility of Category 2 is suggested. However, there were no positive results in vivo tests (negative results in the DNA strand break test (in vivo genotoxicity test in somatic cells) using the livers or spleens of mice and rats orally administered (DFGMAK-Doc.12 (1999))) and no supporting data was available for Category 2. Therefore, the classification was not possible due to lack of data. As relevant information, as for in vitro studies, positive results in multiple Ames test (NTP DB (Access on Jun. 2009), DFGMAK-Doc.12 (1999)), in the chromosome aberration test using CHL cells (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)) and in the HPRT test using human lymphoblastoid cells (DFGMAK-Doc.12 (1999)) were reported.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The carcinogenicity criterion is "Carc. Cat. 3; R40" (EU-Annex I (Access on Jun. 2009)) in the EU classification, but its evidence is not clear. In the animal study, on the other hand, in the 2-year administration study via drinking water in male mice, no effects on the mortality were detected, but an increase in the incidence of liver tumors was reported as the only neoplastic changes associated with the administration, and the incidence of liver cancer and total of incidences of adenomas, carcinomas and nodules of the liver increased compared to background control (DFGMAK-Doc.12 (1999)). Therefore, the substance was classified as Category 2 judging comprehensively from the MOA. As relevant information, no evidence on carcinogenicity were indicated in the oral administration study in mice for 630 - 636 days at the dose level of 12.5 mg/kg dosing once a week, and in the dermal administration study in mice for 581 days at the dose level of 50 mg/kg dosing three times a week (DFGMAK-Doc.12 (1999)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, systemic toxicity)		Danger	H370: Causes damage to organs (respiratory system, systemic toxicity)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In the acute inhalation toxicity study in rats exposed to vapor (LC50 value: 0.65 mg/L/1hr = 0.33 mg/L/4hrs), in addition to the signs such as salivation, nasal discharge and dyspnea, etc., pulmonary edema, atelectasis and hydrothorax were noted in the autopsy of the dead animals (DFGMAK-Doc.12 (1999)). Based on the information and judging from the guidance value (estimated from LC50 value), the substance was classified as Category 1 (respiratory system). Moreover, in the acute oral toxicity study in rats (LD50 value: 98 - 133 mg/kg), signs such as reduced activity, irregular breathing, and dazed behavior were observed, and in the acute dermal toxicity study in rats (LD50 value: 129 - 140 mg/kg) signs such as reduced activity, tremor, ataxia, dyspnea, deterioration of the general state of health were also observed (DFGMAK-Doc.12 (1999)). The effects in both routes partly included symptoms of the respiratory system. However, since those effects in combination with deaths occurred at the dose range within Category 1 of the guidance values (estimated from LD50 values in both oral and dermal routes), and since it was difficult to specify the target organs for the effects other than respiratory system, the substance was classified as Category 1 (systemic toxicity). Besides, it was reported in humans that serious hazard from exposure to the vapors was noted, and that the mucous membranes of the nasal and oral cavity and the upper respiratory tract were affected, producing a burning sensation, bronchial constriction, choking and coughing (ACGIH (2001)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	At the interim examination after 30 weeks in the 2-year oral study via drinking water in mice at average dose level of 17 mg/kg/day, it was reported that the incidence of non-neoplastic changes (vacuolation, cytoplasmic changes, cytomegaly, chronic inflammation, hyperplasia, and necrosis) in the liver was increased accompanied by increased liver weights (DFGMAK-Doc.12 (1999)). Based on the information and judging from the guidance values, the substance was classified as Category 2 (liver). In addition, it was reported that the only treatment-related neoplastic changes were the liver tumors at the examination after 2 years (DFGMAK-Doc.12 (1999)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 2 from its 96h-LC50 = 42.7 micromol/L (3.35 mg/L) for fish (Danio rerio) (AQUIRE, 2010).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2 since its acute toxicity is Category 2 and its rapid degrability is unknown.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）