GHS Classification Result

Chemical Name:4-Methyl-2,4-diphenylpent-1-ene
CAS:6362-80-7

Result:
ID: 22A4287
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 116 degC (closed-cup) (Chemical Risk Information Platform (CHRIP) (Access on Jan. 2011): Original literature 15107 Chemical Products) which is over 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though it contains chemical groups (unsaturated bonds: olefins) associated with explosive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the report that the rat LD50 value was estimated to be between 300 mg/kg and 2000 mg/kg (OECD TG 423) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)), the substance was classified as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and the chromosome aberration test using fibroblast cell strains (CHL/IU cells) derived from Chinese hamster lung ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration in rats (OECD TG 422), in addition to low or lower tendency of number of estrous, corpora lutea of pregnancy, number of implantation and implantation index, low or lower tendency of total pups born, live pups born, delivery index, birth index, live pups on day 4 of lactation were also observed at high dose group (720 mg/kg) that induce one of 12 death and low body weights in dams ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the acute oral toxicity study in rats (OECD TG 423), three of six animals died on day 1 after administration at 2000 mg/kg, and in addition to suppression of body weight gain signs of toxicity observed included tremors, clonic convulsions, staining around the lower abdomen or diarrhea. However, no macroscopic abnormalities were noted in both decedents and survivors at necropsy. Furthermore, no abnormalities were detected in clinical signs, macroscopic observation and the other at 300 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Based on the signs of tremors and clonic convulsions observed at 2000 mg/kg, equivalent to Category 2 of the guidance values, it was reported that respiratory paralysis or abnormality in central nervous system was considered as the cause of death ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Thus, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422), minimal to moderate centrilobular swelling of hepatocytes and minimal or slight basophilic changes of hepatocytes in the liver were observed in the groups at 45 mg/kg/day (converted value as that of 90-day study: 14 mg/kg/day) or higher, and minimal hyaline droplet and degeneration in the tubular epithelium in the kidneys were observed in the groups at 180 mg/kg/day (converted value as that of 90-day study: 56 mg/kg/day) or higher. At the end of the recovery period, centrilobular swelling of hepatocytes in the liver and degeneration of tubular epithelium in the kidneys still remained in the group at 720 mg/kg/day (converted value as that of 90-day study: 224 mg/kg/day) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). The changes in the liver were observed over the dose level corresponding to Category 2 of the guidance values, and they were considered to occur hepatic dysfunction accompanied by swelling of hepatocytes, based on the findings such as higher values in gamma-GTP and total bilirubin in blood biochemistry as well as prolongation of prothrombin time and activated partial thromboplastin time and higher values in fibrinogen concentration in hematology ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Therefore, the substance was classified as Category 2 (liver). As for the changes in the kidneys, however, they were accompanied by hyaline droplet in renal tubular epithelium which was specific to male rats and thus were not evidenced to classify.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 48h-EC50 = 0.057 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2003)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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