GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：(2-Hydroxy-4-methoxyphenyl)(phenyl)methanone
CAS：131-57-7
Result：
| ID: | 22A4286 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 value of > 12800 mg/kg bw (HSDB (2007)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on the rat LD50 value of > 16000 mg/kg bw (HSDB (2007)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Insufficient data were available. As relevant information, application of 2.0 to 16.0 g/kg of the substance caused mild to moderate erythema 24 and 48 hours after application in the rabbit test (HSDB (2007)), but the details of the test were unknown. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 based on the document that the substance was used as a sunscreen, the allergic reaction was reported, and the substance was listed as a sensitizer (Contact Dermatitis, Frosch, 4th (2006)). As relevant information, in the human case, photosensitivity was revealed based on the photo patch test with a 42-year-old woman who had the recurrence of sunlight provoked eczematous eruptions (NTP TOX21 (1992), HSDB (2007)). And it was also reported that a 62-year-old man with the clinical history of photosensitivity developed contact dermatitis after usage of sunscreen containing the substance, and revealed positive reactions in patch test (HSDB (2007)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | The substance was classified as "Not classified" based on the negative results in two in vivo mutagenicity tests in somatic cells, both of the micronucleus test using peripheral blood from mice in the 13-week feeding administration (NTP TOX 21 (1992)) and the chromosome aberration test using bone marrow cells of rats orally administered (HSDB (2007)). As relevant information, as for in vitro studies, negative results in the Ames test except for data showing weakly positive results in TA 97 strain with S9 (NTP DB (1985, 1982)) and positive results in the chromosome aberration test using CHO cells with S9 (NTP TOX 21 (1992)) were reported. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the study in male and female mice continuously administered by diet at the concentration of 1.25, 2.5 and 5.0% for 98 days from 7-day before mating, in 2.5 and 5.0% groups, consistently higher food consumption and consistently lower body weights were observed, the number of live pups per litter was significantly reduced, pup survival was significantly lower than the control value during lactation and nursing period (NTP RACB88076 (1990)). However, based on the results of the present study, it was concluded that this substance caused systemic toxicity, but had minimal effects on fertility and reproduction (NTP RACB88076 (1990)). In addition, there was no other valid information to evaluate the reproductive toxicity. Therefore, the substance was classified as "Classification not possible". |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In the 13-week feeding studies in rats and mice, the NOAELs were reported to be 25000 ppm (converted value as that of the actual intake: 1250 mg/kg/day) in rats and 6250 ppm (converted value as that of the actual intake: 313 mg/kg/day) in mice, based on renal lesions such as papillary necrosis and/or dilatation of renal tubules (NTP TOX21 (1992)). Thus, the classification corresponded to "Not classified" for oral route. While in the 13-week dermal study in mice, it was reported that the epididymal sperm density was decreased at 23 mg/kg/day or higher (NTP TOX21 (1992)). However, the details were unknown and none of the test data were available for inhalation exposure. Therefore, "Classification not possible" was justified for the classification for specific target organ toxicity (repeated exposure). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 72h-EC50 = 0.67 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 4% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1988)). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |