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GHS Classification Result

Chemical Name：3a,4,7,7a-Tetrahydro-1H-indene
CAS：3048-65-5

Result：


ID:	22A4279
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Although measurement method of the flash point 38 degC (unknown) (Chemical Risk Information Platform (CHRIP) (Tokyo Chemical Industry Co., Ltd. MSDS) (Access on Jan. 2011)) is unknown, it is estimated that the flash point measured by the closed-cup method fall within the range of >= 23 degC and <= 60 degC. Therefore the substance was classified into Category 3.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Since its autoignition temperature is 370 degC (Chemical Risk Information Platform (CHRIP) (Tokyo Chemical Industry Co., Ltd. MSDS) (Access on Jan. 2011)), it is considered that the substance does not ignite at room temperature.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat study (OECD TG 423) that administration of 2000 mg/kg caused no death and 5000 mg/kg was estimated to be the lethal dose ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)), the substance was classified as "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Insufficient data were available. Although the rabbit LD50 value of 14.1 mL/kg (converted value as the actual amount of the test substance: 13.1 g/kg) was reported in the "List 3" information source (RTECS (2004)) designated in the GHS classification guidance for the Japanese government, details were unknown.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test (OECD TG471, GLP-compliant) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)) and positive results in the chromosome aberration test using Chinese hamster cultured cells (CHL/IU) (OECD TG473, GLP-compliance) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)) were reported.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant) (dose levels: 0, 67, 200 and 600 mg/kg/day), effect on reproductive performance of male animals was not observed even at 600 mg/kg group, whereas in females, reduction of the number of corpora lutea of pregnancy was observed at 600 mg/kg, which was considered to cause prolonged gestation length and reduction of implantation number observed at the same dose. For the next generation, numbers of pups born and those born alive were decreased at the 600 mg/kg group ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)). In addition, decreased body weight gain was seen in male and female rats at 200 and 600 mg/kg groups ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)). The reproductive toxicity was observed at the dose levels, causing general toxicity to parent animals. Therefore, the substance was classified as Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	In the acute oral toxicity study in rats (OECD TG423), no deaths occurred at the dose levels of 300 and 2000 mg/kg, and slightly decreased locomotor activity and ptosis, rough hair, transient salivation and/or reddish tear were observed as the changes in the general conditions at 2000 mg/kg, but all of these disappeared on the following day. No macroscopic changes of the internal organs were observed in both 300 and 2000 mg/kg groups at necropsy ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Based on the information, although "Not classified" was applicable for oral route, the classification was not possible due to lack of information on the effects via the dermal and inhalation routes.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant) (dose levels: 0, 67, 200 and 600 mg/kg/day), slight to moderate hyaline droplet deposition and occurrence of eosinophilic bodies in the epithelium of proximal tubules of the kidneys were observed in male groups at 67 mg/kg/day (converted value as that of 90-day study: approx. 33 mg/kg/day) or more, and trend to increase of rate of slight regeneration in the renal tubules was additionally observed at 200 mg/kg/day (converted value as that of 90-day study: approx. 100 mg/kg/day) or more. However, since it was reported that these changes were considered as specific phenomenon of male rats with no toxicological significance ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)), they were not evidenced to classify. Furthermore, the changes seen at 200 mg/kg/day (converted value as that of 90-day study: approx. 100 mg/kg/day) were suppression in body weight gain in both sexes and increases in weights of both the liver and kidneys in males or females without any other treatment-related changes containing histopathological changes. Thus, "Not classified" was applicable for oral route, but the effects were unknown in the other routes due to no data. Therefore, "Classification not possible" was justified as the classification for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 48h-EC50 = 0.73 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1996).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1998)).
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）