GHS Classification Result

Chemical Name:Diphenyldisulfane
CAS:882-33-7

Result:
ID: 22A4277
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
As the result of the rat study (OECD TG423, GLP-compliant), the approximate LD50 value was estimated more than 300 mg/kg and 2000 mg/kg or less ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2004)). The substance was classified as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results were reported in the Ames test ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2004), JECFA No. 973 (2000)) and the chromosome aberration test using Chinese hamster CHL cells ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2004)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration in rats (OECD TG 422, GLP-compliant), for reproductive function, no changes associated with the administration were observed in any of the estrus cycles, copulation index, fertility index, delivery index, gestation length, number of corpora lutea, number of implantation sites, implantation index, gestation index, parturition and lactation behavior at the dose levels that cause general toxicity in parental animals. And in neonatal examination, no changes associated with the administration were observed in any of the numbers of offspring, number of live offspring, sex ratio, viability index at day 0, viability index at day 4, external examination, clinical sign, body weight and necropsy at the dose levels that cause general toxicity in parental animals ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2004)). However, since the data about the development of the offspring containing teratogenic effects were insufficient, the classification was not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the acute oral toxicity study in rats (OECD TG423, GLP-compliant), no treatment-related abnormalities were found in mortality, clinical signs of toxicity and necropsy at 300 mg/kg. However, emaciation, lateral position, hunchback position, decreased locomotor activity, bradypnea was observed at 2000 mg/kg, and all animals in dead or sacrificed at moribund stage revealed hemorrhage of glandular stomach, and protrusion area and thickening of the wall of the forestomach at necropsy. Even in the survivors, the protrusion area was also found ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2004)), however, it was described that these changes were considered as a cause of death or exhaustion probably attributed by treatment-related irritation to gastric mucosa ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2004)). Furthermore, the small size of the thymus and spleen in the decedents, as well as the small size of the thymus in the survivors, were observed, but it was also reported that these changes were considered as the effects attributed to exhaustion or stress ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2004)). Based on the information, because the effects on the stomach were regarded as the local effects and the cause of deaths were attributed to stress, these findings were not adopted as the basis to classify. No reports were available for the other routes. Thus, the classification was not possible.
9 Specific target organ toxicity - Repeated exposure Category 2 (hematopoietic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration in rats (OECD TG 422, GLP-compliant), increase in the spleen weight was observed in both sexes of 30 mg/kg/day group ( converted value as that of 90-day study: approx. 13 mg/kg/day), accompanied histopathologically by hemosiderin deposition and enhancement of erythroid extramedullary hematopoiesis in the spleen in both sexes, and enhancement of erythroid hematopoiesis in the bone marrow of the femur in females. It was reported that hematological changes considered as related to hematopoietic system involved those suggesting anemia such as low values of the erythrocyte count in both sexes, low value of hemoglobin concentration and high value of reticulocyte count in males ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2004)). Thus, the substance was classified as Category 2 (hematopoietic system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 48h-EC50 = 0.0085 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002; BIOWIN).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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