GHS Classification Result

Chemical Name：1,3-Dichloropropane
CAS：142-28-9

Result：
ID: 22A4203
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 21.1 degC (closed-cup) (HSDB (2002)) is < 23 degC and initial boiling point reported 120.9 degC (Lide (90th, 2009)) is > 35 degC, the substance corresponds to Category 2.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 480 degC (GESTIS (Access on Oct. 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was reported that the substance was irritating to the skin (HSDB (2002)). In human cases, exposure of the substance caused severe skin irritation with marked inflammatory response in the epidermal and subcutaneous tissues (HSDB (2002)). Based on the information, the substance was classified as Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data were available. As relevant information, it was reported that the substance was irritating to the eye (HSDB (2002)). In the rabbit test of 1,1-dichloropropane, the related substance of concerned substance, the degree of damage was 2 in the maximum scale of 10 (most severe injuries: 10). (HSDB (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 based on the classification as "Group 2" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits vol. 52 (2010)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, positive results in the Ames test were reported (NTP DB (Access on Nov. 2010)).
6 Carcinogenicity Classification not possible - - - - No data were available. As relevant information, in the carcinogenicity test by inhalation of 1,2- dichloropropane, increase in the incidence of tumors in nasal cavity in both sexes of rats, of adenomas in the Harderian gland in male mice, and of tumors in lung containing cancer in bronchioles-alveolar epithelium in female mice was observed. These was concluded as the evidence of carcinogenicity (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2005)).
7 Reproductive toxicity Classification not possible - - - - No data were available. As relevant information about 1,2-dichloropropane, it was reported that in the two-generation reproduction study in rats, decrease in birth weights and increased mortality of neonates were observed at the dose causing effects to parental animals (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005))
8 Specific target organ toxicity - Single exposure Category 2 (liver, kidney, blood system, central nervous system, respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (liver, kidney, blood system, central nervous system, respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Hepatic injury and renal failure were noted in humans as acute effects via oral and by inhalation. And in the one case, it was reported that acute renal necrosis was shown by the examination of renal biopsy (HSDB (2002)). By acute inhalation exposure to vapors, disseminated intravascular coagulation and hemolytic anemia were reported (HSDB (2002)). Furthermore, the following were described as clinical signs after vapor inhalation: gasping, respiratory arrest, coughing, substernal pain and extreme respiratory distress at high concentrations over 1500 ppm; depression of central nervous system and moderate irritation of the respiratory system at lower concentrations; malaise, headache, chest and abdominal discomfort and irritability noted after inhalation exposures were reported to persist for several weeks and sometimes perhaps for several years (HSDB (2002)). Meanwhile, damage of the liver and kidneys, effects on central nervous system and irritation to the lungs were described as the hazardous effects of the substance in the manual for human poisoning therapy (DHP, 13th (2002)). Based on the information, liver, kidneys, blood, central nervous system and respiratory system were considered as the target organs, and the information was derived from the "List 2" information source designated in the GHS classification guidance for the Japanese government. Therefore, the substance was classified as Category 2 (liver, kidney, blood, central nervous system, respiratory system) and Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data were available. As relevant information on 1,2-dichloropropane, there were some descriptions that hemolytic anemia, effects on the liver and kidney function in humans were seen in humans (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005), ACGIH (2006)), and that degeneration of olfactory epithelium was seen in the animal studies (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 24h-LC50 = 39 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (BIOWIN).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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