GHS Classification Result

Chemical Name：Methyl-endo-methylenetetrahydrophthalic anhydride
CAS：25134-21-8

Result：
ID: 22A4194
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
5 Gases under pressure Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
6 Flammable liquids Not classified - - - - Although measurement method of the flash point 135 degC (GESTIS (Access on Oct. 2010)) is unknown, it is estimated that the flash point measured by the closed-cup method is > 93 degC. Therefore, the substance is classified as "Not classified".
7 Flammable solids Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 450 degC (GESTIS (Access on Oct. 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid at room temperature (Sax (11th, 2004)).
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 958 mg/kg (OECD Study, GLP-compliant) (RTECS (2009), original literature: HPV184 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Cyclic Anhydrides. pdf (http://www. epa. gov/HPV/pubs/summaries/viewsrch. htm) : (2001)), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 value of 4920 mg/kg bw and the rabbit LD50 value of > 2000 mg/kg (RTECS (2009), original literature: HPV184 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Cyclic Anhydrides. pdf (http://www. epa. gov/HPV/pubs/summaries/viewsrch. htm) : (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid at room temperature (Sax, 11th (2004)).
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data were available. The lethal concentration of 0.75 mg/L was reported based on the aerosol 4-hour exposure (RTECS (2009), original literature: HPV184 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Cyclic Anhydrides.pdf (http://www. epa. gov/HPV/pubs/summaries/viewsrch. htm) : (2001)). Since the value did not provide the basis for the classification, the classification was not possible.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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