GHS Classification Result

Chemical Name:Trimethylbenzylammonium chloride
CAS:56-93-9

Result:
ID: 22A4180
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Since the substance is an organic compound containing chlorine which is ionically bonded to nitrogen atoms, the substance was classified as "Not classified".
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 250 mg/kg bw (NTP TOX 57 (2000)), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - In the micronucleus test using peripheral blood obtained from mice orally administered for 13 weeks (in vivo mutagenicity test in somatic cells), positive results were reported (NTP DB (1993)). However, the response in the positive data of this test was very weak and the test method was not compliant with the guidelines. No other available data to determine the classification of this substance, therefore, the classification was not possible. As relevant information, as for in vitro studies, negative results in the Ames test ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council), (Access on May 2010), NTP DB (1984)) and pseudopositive in the chromosome aberration test using CHL cells ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on May 2010)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In rats administered orally at doses of 175 mg/kg or more, in addition to the occurrence of deaths, muscarinic cholinergic symptoms such as salivation and chromodacryorrhea appeared, and these symptoms were relieved by atropine injection (NTP TOX 57 (2000)). In the 16-day oral dose study in rats (dose levels: 16-250mg/kg), after the initial administration , all rats in the groups at 125 mg/kg or more died, and they reveled clinical symptoms such as abnormal breathing, ataxia, nasal and eye discharges and tremors (NTP TOX 57 (2000)). These findings after oral administration were observed in the dose level equivalent to Category 2 of the guidance values, and based on the descriptions mentioning that the substance was capable of stimulating both nicotinic and muscarinic receptors and acted at the same ganglionic site as acetylcholine (NTP TOX 57 (2000)). Based on the information, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the 28-day oral dose toxicity study in rats (dose levels: 30 - 120 mg/kg/day), the treatment-related changes were the following: suppression of body weight gain, high values of hemoglobin concentration, MCV (mean corpus volume), and MCH (mean concentration of hemoglobin) at 120 mg/kg/day (converted dose level as that of 90-day study: 37 mg/kg/day), and clinical signs of salivation and lacrimation at 60 mg/kg/day or more ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)). Moreover, in the 13-week oral toxicity studies in rats and mice (dose levels: 12.5 - 100 mg/kg/day), deaths occurred at the highest dose of 100 mg/kg/day, and the deaths were reported as the consequence of pharmacological effects on the cardiovascular system. It was also reported that cholinergic effects such as salivation, chromodacryorrhea, lacrimation, miosis, abnormal gait and tremors were observed in non-lethal dose levels (NTP TOX 57 (2000)). Based on the descriptions mentioning that the substance was capable of stimulating both nicotinic and muscarinic receptors and acted at the same ganglionic site as acetylcholine (NTP TOX 57 (2000)), and taking into consideration with the doses tested corresponding to Category 2, the substance was classified as Category 2 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 2 from its 48h-LC50 = 6.94 mg/L for crustacea (Daphnia pulex) (AQUIRE, 2011).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (4w-BOD degradation rate tested by OECD TG301C = 1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1984)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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