Chemical Name:Ethyl p-aminobenzoate
CAS:94-09-7
ID: | 22A4178 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2010 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen which is chemically bonded only to carbon. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 value of 3042 mg/kg (PATTY, 5th (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
The substance was reported to have sensitization potential in many documents containing the maximization test and Buehler test using guinea pigs (ECETOC TR 77 (1999)). The substance was recognized as one of the most frequently encountered skin sensitizer in Western Europe and North America with clinical sensitization rate ranging from 4 - 5% (ECETOC TR 77 (1999)). The substance was used as medicine for oral administration and for external use, and side effect generally reported was hypersensitivity (rash, itch, etc.) (Handbook of Japanese Pharmaceutical Drugs (2010)), and the substance was concluded as skin sensitizer for humans (ECETOC TR 77 (1999)). Based on these documents, the substance was classified as Category 1. | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Insufficient data were available. As relevant information, it was reported that no association with birth defects and maternal use of this substance was found (PATTY, 5th (2001)). However, detail was unknown. |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood) | Danger | H370: Causes damage to organs (blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was used as a topical anesthetic or analgesic drugs, there were multiple cases of methemoglobinemia even at the clinical dosage (PATTY, 5th (2001)). Hematotoxicity (methemoglobinemia) was described in the package insert of the drug as one of the side effects when ingested the substance used as a drug (Handbook of Japanese Pharmaceutical Drugs (2010), HSDB (2005)). Based on the information described above, the substance was classified as Category 1 (blood). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the information that hematotoxicity (methemoglobinemia) was described in the package insert of the drug as one of the side effects when ingested the substance used as a drug (Handbook of Japanese Pharmaceutical Drugs (2010), HSDB (2005)), the substance was classified into Category 1 (blood). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 96h-LC50 = 7.2 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2011). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2 and data on rapid degradation are not available. | |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |