GHS Classification Result

Chemical Name：2-Isocyanatoethyl methacrylate
CAS：30674-80-7

Result：
ID: 22A4173
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point reported 97 degC (closed-cup) (Chemical Risk Information Platform (CHRIP) (Access on Sept. 2010)) is over 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (unsaturated bond) associated with self-reactive properties in the molecule, but classification is not possible due to lack of additional data.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 670 - 2000 mg/kg (RTECS (1997), original literature: Drug and Chemical Toxicology, 3 (4), 381-392 (1980)), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 4 ppm/6hrs (= 4.9 ppm/4hrs) (RTECS (1997), original literature: Drug and Chemical Toxicology, 3 (4), 381-392 (1980)), the substance was classified as Category 1. The LC50 value (4 ppm) was lower than 90% of the saturated vapor pressure concentration, the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - The classification was not possible due to lack of the data of this substance. As relevant information, as for the effects on human, isocyanates were irritating to the skin and the mucous membranes, and caused itching or eczema (HSDB (2002)).
3 Serious eye damage/eye irritation Classification not possible - - - - The classification was not possible due to lack of the data of this substance. Although there was little information about the effects of isocyanates on human eyes, it was reported that lacrimation was often found, conjunctivitis was rare (HSDB (2002)).
4 Respiratory sensitization Classification not possible - - - - There is information that methacryloyloxyethyl isocyanate is a respiratory sensitizer (HSDB (2002)). However, since it was the datum from the "List 2" information source designated in the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible". No information on evidence data or referenced literature was provided.
4 Skin sensitization Classification not possible - - - - There is information that methacryloyloxyethyl isocyanate is a skin sensitizer (HSDB (2002)). However, since it was the datum from the "List 2" information source designated in the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible". No information on evidence data or referenced literature provided.
5 Germ cell mutagenicity Classification not possible - - - - In the dominant lethal test using male rats by inhalation exposure (in vivo inheritable mutagenicity test in germ cells), the dominant lethal mutation was not found (HSDB (2002)). However, the test was conducted at very low concentration (0.00025 - 0.25 ppm) because of severe inhalation toxicity of this substance, therefore, the negative results were doubtful. As relevant information, no other data were obtained for in vivo or in vitro studies and effects to somatic cells were also unclear. Consequently, the classification of this substance was not possible due to lack of data.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data were available. As relevant information, it was reported that pre-implantation mortality was observed in rats by exposure of the substance (HSDB (2002)). However, there was no description about evidence or original paper, and the details were unclear.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information