GHS Classification Result

Chemical Name:1-Heptanol
CAS:111-70-6

Result:
ID: 22A4168
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point reported 70 degC (closed-cup) (ICSC (2005)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 275 degC (ICSC (2005)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 values of 6.2 g/kg (male), 5.5 g/kg (female) and 3.25 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 values of approximately 2 g/kg and > 5 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No death for 4-hour exposure of the saturated vapor was reported (PATTY, 5th (2001)). Since the report did not provide the basis for classification, the classification was not possible. The saturated vapor pressure concentration at 25 degrees centigrade is 1.35 mg/L.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Insufficient data were available. Although the mouse LC50 value of 6.6 mg/L (1390 ppm) was reported (PATTY, 5th (2001)), the exposure time was unknown, and the classification was not possible. The LC50 value was higher than the saturated vapor pressure concentration (1.35 mg/L), the criterion value for dust/mist were adopted.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
The substance was classified as Category 2 based on the documented case of "moderately irritating" resulted from the rabbit test in which undiluted substance was applied for 24 hours (PATTY, 5th (2001)). As relevant notes, it was reported that the occlusive application of 1% of the substance in petrolatum for 48 hours caused no irritation to human skin (PATTY, 5th (2001), original literature: D. L. J. Opdyke, Food Cosmet. Toxicol.13, p 697-698 (1975)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
The substance was classified as Category 2 based on the documented case of "moderately irritating" resulted from the rabbit test (PATTY, 5th (2001)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In the human maximization test with 20 volunteers, the substance didn't cause skin sensitization (PATTY, 5th (2001)). However, no further information or details of the test were provided in the original report (Food Cosmet. Toxicol. 13, 697-698 (1975)). Thus, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The classification was not possible due to lack of data. As relevant information, there was a description referring to the NOEL of 50 mg/kg, the highest dose in the 6-month oral toxicity study in rabbits (JECFA FOOD ADDITIVES SERIES 40 (1998)). In the inhalation study in rats and rabbits, conjunctival redness and decrease in blood cholinesterase activity were observed. And it was also reported that inhalation of 0.18 - 0.35 mg/L (38 - 74 ppm) 2hrs/day for 4.5 months caused minor hematologic changes and some unspecified histological changes (PATTY, 5th (2001)). However, there were no concrete descriptions in these data regarding the concentrations and duration of the exposure, or the animal species tested.
10 Aspiration hazard Classification not possible - - - - Based on the fact that the substance is a n-primary alcohol with carbon numbers C3 to C13 and coefficient of kinematic viscosity is 7.1 mm2/s (coefficient of viscosity: 5.81 mPa*s (25 degrees centigrade), density: 0.822 g/cm3 (Lide, 90th (2009)), the substance is classified as Category 2 of the UN-GHS criteria. However, the classification was not possible by the JIS classification criteria. Additionally, as related information, it was reported that inhalation of 0.2 mL of this substance caused instant death of 10/10 rats due to respiratory failure (PATTY, 5th (2001)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 96h-LC50 = 18 mg/L for fish (Oryzias latipes) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classification using chronic toxicity data: although adequate data on rapid degrability are not available, the substance is classified as "Not classified" from 21d-NOEC = 1.4 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000). Classification using acute toxicity data for the trophic levels for which chronic toxicity data are lacking: although adequate data on rapid degradability are not available, the substance is classified into Category 3 from 96h-LC50 = 18 mg/L for fish (Oryzias latipes) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000). The substance is classified into Category 3 by comparing the outcomes mentioned above.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information