GHS Classification Result

Chemical Name:Vinyl methyl ether
CAS:107-25-5

Result:
ID: 22A4165
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place.
Flammable range is 1.9 - 32.0% (Ullmanns (E) (6th, 2003)) and it is applicable more than 12%. And it is rated as Division 2.1 in UNRTDG (UN1087), therefore it is classified into Category 1.
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not classified - - - - Since the substance is classified as Division 2.1 in UNRTDG (UN1087), it is not an oxidizing gas.
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The substance is gas and its critical temperature is 167.85 degC (Matheson (7th, 2001)) which exceed +65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gas substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 value of 3660 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 value of >8000 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not classified - - - - Based on the results that 4-hour exposure at 64000 ppm to 6 rats caused no mortality (IUCLID (2000)) and the rat LC50 value was > 5.3 mg/L/4hrs (> 2202 ppm/4hrs) (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - In the rabbit test, no irritation was reported (IUCLID (2000)). But the substance was classified as "Classification not possible" because the substance is gaseous (boiling point is 12 degree centigrade) and no details of testing methods were provided. As relevant notes, liquid or concentrated vapor of the substance revealed frostbite to the human skin (HSDB (2002)). It was also reported that contact with the substance revealed burn of the skin and direct skin contact might cause frostbite (HSFS (2001)).
3 Serious eye damage/eye irritation Classification not possible - - - - In the rabbit test, no irritation was reported (IUCLID (2000)). However the substance was classified as "Classification not possible" because the substance is gaseous (boiling point is 12 degree centigrade) and no details of testing methods were provided. As relevant notes, liquid or concentrated vapor of the substance caused eye irritation (HSDB (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow obtained from mice exposed by inhalation (in vivo mutagenicity test in somatic cells) (IUCLID (2000)). These results mentioned above were obtained from retrial study. In the former test using male and female mice in accordance with the similar protocol, clear results were not obtained though due to the increase in micronuclei in males at the high dose (IUCLID (2000)). As relevant information, as for in vitro study, negative results in the Ames test were reported (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was described that ethers generally had narcotic action and it was indicated that structurally similar vinyl ethers (the substance and isopropyl vinyl ether) possessed depressive action of central nervous system and anesthetic action in the laboratory animals (HSDB (2002)). In addition, as symptoms following exposure to humans, headache, dizziness, excitation, loss of consciousness were described (HSDB (2002)). Based on the information, the substance was classified as Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the 28-day inhalation toxicity study in rats (OECD TG 412, GLP-compliant) exposed to the substance at the concentrations of 500, 3500 and 25000 ppm, slight prolongation of prothrombin time and slight decrease in total protein concentration were observed in males of all treatment groups. The signs consisting of restlessness and piloerection, and changes in the liver weight were observed in the highest dose level (25000 ppm), and suppression of body weight gain was observed in the doses of 3500 ppm or more. However, no remarkable changes were found at necropsy. The only histopathological change was atrophy of the nasal olfactory epithelium in the highest dose group. The NOAEL of 3500 ppm (converted concentration as that of 90-day study: 1089 ppm) was reported for females (IUCLID (2000)). For males, the effects at 3500 ppm were slight, and in another 28-day inhalation toxicity study in male rats (OECD TG 412, GLP-compliant), no effects as described above were noted, and the NOAEL of 1500 ppm (converted concentration as that of 90-day study: 467 ppm) was reported (IUCLID (2000)). Based on the information, since the substance was gasiform by definition of GHS and the NOAELs in the 28-day repeated inhalation studies in rats (OECD TG412, GLP-compliant) were over the upper limit (250 ppm) of the range of the guidance values, "Not classified" was justified.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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