GHS Classification Result

Chemical Name：Methyl lactate
CAS：547-64-8

Result：
ID: 22A4163
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 49 degC (closed-cup) (HSDB (2002)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 385 degC (HSDB (2002)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the description that the rat LD50 value was > 2000 mg/kg and no mortality was observed (OECD TG 401, GLP-compliant) (Regul Toxicology and Pharmacology 27, RT971175 (1998)), the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The rat LC50 value of > 5.03 mg/L/4hrs (1182 ppmV) was reported (OECD TG 403 and GLP-compliant) (Regul. Toxicology and Pharmacology 27, RT971175 (1998)). Since the value did not provide the basis for the classification, the classification was not possible. As the toxicity value (1182 ppmV) was lower than 90% of saturated vapor pressure concentration, the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant notes, the substance was reported as non irritating (Regal Toxicology and Pharmacology 27, RT971175 (1998)). But no details of test methods and condition such as animal species, application volume, and exposure time were provided.
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data were available. As relevant notes, the substance was reported as non irritant in the guinea pig test (Journal of Pharmacology Pharmacol 11, p150-155. (1959)). But no details about methods and results were provided. The substance was classified as "Xi; R36/37" in the EU classification (EC-JRC (ESIS) (Access on Sep. 2010)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the acute oral toxicity study in rats (OECD TG 401, GLP-compliant), clinical sign was piloerection only, no deaths occurred and no abnormalities were detected at necropsy at 2000 mg/kg. Based on the information, "Not classified" was justified for oral route. Meanwhile, in the acute inhalation toxicity study in rats (OECD TG 403, GLP-compliant), no deaths, but hyperpnea in clinical signs, and discoloration and irregular surface of the lungs in necropsy were reported at the concentration of 5.03 mg/L/4hrs (Regul. Toxicology and Pharmacology, 27, RT971175 (1998)). However, no further details were shown. Moreover, no data were available for dermal application. Therefore, the classification for specific target organ toxicity (single exposure) was determined as "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" from its 48h-EC50 = 749 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 1000 g/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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