GHS Classification Result

Chemical Name：1,2-Bis(2-chloroethoxy)ethane
CAS：112-26-5

Result：
ID: 22A4162
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - The flash point 121 degC (open-cup) was obtained (HSDB (2008)) and it is estimated that the flash point measured by the closed-cup method is >= 93 degC. Based on this information, the substance was classified as "Not classified".
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen and chlorine which are chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The rat LD50 values of 269 mg/kg (male) and 353 mg/kg (female) were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)), and the value for males corresponded to Category 3 and the value for females corresponded to Category 4. Selecting the category of greater hazard, the substance was classified as Category 3.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 value of 1410 mg/kg (HSDB (2003)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant information, as for the datum from "List 3" information source designated in the GHS classification guidance for the Japanese government, it was reported that non-occlusive application of 500 mg of the substance to rabbit skin caused mild irritation (RTECS (2003)). But no details were provided.
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data were available. As relevant information, as for the datum from "List 3" information source designated in the GHS classification guidance for the Japanese government, it was reported that instillation of 100 mg of the substance to rabbit eye caused severe irritation in the standard Draize test (RTECS (2003)). But no details were provided.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, positive results in the bacterial reverse mutation test and the chromosome aberration test using cells derived from Chinese hamster lung were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), Access on Aug. 2010).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral toxicity study in rats, decrease in locomotor activity and salivation were observed in all treatment groups (180 - 600 mg/kg), and diarrhea, lachrymation, prone position, lateral position, and hypothermia were additionally noted in decedents. Diarrhea, lachrymation and prone position were also observed in survivors, but disappeared on day 2 of post-administration ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). In necropsy findings of the study, diffuse red area/spots in the lungs was noted in decedents of both sexes at 400 mg/kg or higher, indicating the target organ of the lungs ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council)) (Access on Aug. 2010)). Based on the information, the substance was classified as Category 2 (lung).
9 Specific target organ toxicity - Repeated exposure Category 2 (heart) Warning H373: May cause damage to organs through prolonged or repeated exposure (heart) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 28-day repeated dose oral toxicity study in rats, salivation was observed in all treatment groups, and signs such as decrease in spontaneous activity, emaciation, piloerection, stained fur and abnormal respiratory sound were observed in decedents caused at high dose group at 200 mg/kg/day. In blood biochemistry, high values of ALT activity and potassium concentration and low value of sodium concentration were noted in males of 200 mg/kg/day group. Histopathologically, degeneration and/or necrosis of myocardial cells and reflective cell reactions in the heart were observed in both sexes of 200 mg/kg/day group ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). Based on the results that deaths occurred and histopathological changes in the heart caused at 200 mg/kg/day (converted dose level as that of 90-day study: 62.2 mg/kg/day), equivalent to Category 2, the substance was classified as Category 2 (heart).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information