GHS Classification Result

Chemical Name：2-Ethylhexyl thioglycolate
CAS：7659-86-1

Result：
ID: 22A4159
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
5 Gases under pressure Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 56 degC (closed-cup) (GESTIS (Access on Aug. 2010)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010)).
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values of 390, 348, 303 (male) and 334 (female) mg/kg bw (IUCLID (2000)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the report that the rat LD50 value was > 2000 mg/kg bw and the mortality was 20% at 2000 mg/kg (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid at room temperature (GESTIS (Access on Aug. 2010))
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - The rat LCLo value of > 0.51 mg/L/6hrs (0.765 mg/L/4hrs) was reported (IUCLID (2000)). Since only this value did not provide the basis for classification, the substance was classified as "Classification not possible". The exposure concentration (0.51 mg/L) was higher than the saturated vapor pressure concentration (0.15 mg/L), the criterion values for dust/mist were adopted.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test (OECD TG404, GLP-compliant), average scores of each 3 animals at 24, 48 and 72 hours after application were 1.3, 1.7, and 1.3 for erythema, 0.0, 0.0, and 0.3 for edema, respectively, and the symptoms were all reversible within 6 days and 3 days respectively. Thus, the substance was concluded as slightly irritating (IUCLID (2000)). Because the average score of erythema or edema was less than 1.5 in at least two of three animals, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In the eye irritation test using 3 rabbits (OECD TG404, GLP-compliant), modified maximum average score was 0/110 (ECETOC TR 48 (1998)). The substance caused no effect on the eye and resulted as not irritating (IUCLID (2000)). Based on these documents, the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 based on the documented case of "sensitizing" resulted from the guinea pig maximization test (OECD 406, GLP-compliant) in which positive rate was 50% (5/10) (IUCLID (2000)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test (IUCLID (2000)) and ambiguous results in the chromosome aberration test using Chinese hamster V79 cells (IUCLID (2000) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It was reported that exposure to rats by inhalation of 0.51 mg/L/6hrs (0.765 mg/L/4hrs) caused no deaths, no toxic signs and no abnormalities in necropsy (IUCLID (2000)). And it was reported that marked decrease in the spontaneous activity was observed in rats on day 2 after dermal application at 2000 mg/kg, but the survivors recovered on day 5 and afterwards, with no abnormalities in necropsy and mortality rate of 20% (IUCLID (2000)). As either data lacked sufficient information, the classification was not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 4-week feeding study in rats, significant decreases in leukocyte and lymphocyte counts were observed as well as significant increases in the liver and kidney weights. However, no effects on clinical signs, body weight gains or food consumptions were seen in the high dose group of 2000 ppm (converted dose level as that of 90-day study: 52.3 mg/kg/day) and no treatment-related histopathological adverse effects on organs were noted (IUCLID (2000)). All of the test doses were within the range of the guidance values, and thereby the classification was not possible from the results of the study. For other data, there were information regarding the 14-day feeding study in rats and 2-week repeated dermal application studies in rats and guinea pigs (IUCLID (2000)). The 14-day feeding study was the preliminary study using a small number of animals (two animals per sex per dose). The 2-week repeated dermal application studies were conducted by setting only one dose level and no detail about the results were available. Thus, the information was unable to use for classification due to shortage of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 48h-EC50 = 0.38 mg/L for crustacea (Daphnia magna) (SIDS, 2010).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 80, 8, 7% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2001)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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