GHS Classification Result

Chemical Name:Diethylene glycol bis(allyl carbonate)
CAS:142-22-3

Result:
ID: 22A4154
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point reported 192 degC (closed-cup) (NFPA (13th, 2006)) is >= 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (unsaturated bonds) associated with self-reactive properties in the molecule, but classification is not possible due to lack of additional data.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on two LD50 values for rats of 350 mg/kg and 515 mg/kg (IUCLID (2000)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Based on the LD50 value of > 3000 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The rat LCLo value of 0.73 mg/L/1hr (= 0.183 mg/L/4hrs) (IUCLID (2000)) was the only data available. Since the value did not provide the basis for the classification, the classification was not possible. The test concentration (0.73 mg/L) was higher than the saturated vapor pressure concentration (0.000954 mg/L), the substance was considered as mist.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In occupational exposure, a 19-year-old woman who was employed to inject diallylgycol carbonate liquid monomer into lens molds developed contact dermatitis. During work, spilled monomer occasionally splashed on her hands and arms. After 2 weeks, the patient developed blisters and edema of the back of her hands, forearms and knees, and was hospitalized (HSDB (2002)). By subsequent patch test carried out in ten volunteers with 1% solution of the substance, the irritant nature of the product was confirmed since minimal or mild edema were observed (HSDB (2002)). In addition to the conclusion that the case mentioned above showed an allergic contact dermatitis by the substance, there was the description that the substance was also skin irritant (HSDB (2002)). Based on these documents, the substance was classified as Category 2. As relevant notes, non irritating result was reported in the rabbit test (IUCLID (2000)), and severe result was also reported in the datum from the "List 3" information source designated in the GHS classification guidance for the Japanese government (RTECS (2010)).
3 Serious eye damage/eye irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not irritation" (IUCLID (2000)) resulted from the rabbit test (Directive 84/449/EEC, B4, GLP-compliant).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In occupational exposure, a 19-year-old woman who was employed to inject diallylgycol carbonate liquid monomer into lens molds developed contact dermatitis. During work, spilled monomer occasionally splashed on her hands and arms. After 2 weeks, the patient developed blisters and edema of the back of her hands, forearms and knees, and was hospitalized (HSDB (2002)). In the patch test which was carried out in order to deny the possibility of allergic contact dermatitis, she was highly sensitive to the substance, and revealed a positive reaction even at the low concentration of 0.001%. The authors conclude that the patient developed an allergic contact dermatitis to the substance (HSDB (2002)). However, since it was only one case report, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the dermal administration study using pregnant rabbits during the organogenetic period, death was observed in 7 of 18 dams in the high dose group (1.0 mL/kg bw/day) group, and decreased body weight, pale foci in liver, kidneys, and mesentery at necropsy were observed in the mid dose group (0.5 mL/kg bw/day) or more (HSDB (2002)). As reproductive effects, significantly higher incidence of microphthalmia was observed in the mid dose group or more (IUCLID (2000), HSDB (2002)). Therefore, the substance was classified as Category 2. In addition, significantly increased abortions were observed in dams in the high dose group (IUCLID (2000), HSDB (2002)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there was an investigation result stating that 7 of 25 workers developed signs of liver disease while handling this substance (IUCLID (2000)), no further details were given. Classification was not possible due to lack of sufficient data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 96h-LC50 = 0.15 mg/L for fish (Brachydanio rerio) (IUCLID, 2000).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified as "Not classified" since it is rapidly degradable (BOD: 74%, TOC: 96%, GC: 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002)) and its bioaccumulation potential is estimated to be low (Log Kow = 1.54 (PHYSPROP Database, 2011)) though its acute toxicity is Category 1.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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