GHS Classification Result

Chemical Name：N-Isopropylacrylamide
CAS：2210-25-5

Result：
ID: 22A4142
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - Although there are chemical groups (unsaturated bond) present in the molecule associated with self-reactive properties, classification is not possible due to lack of additional data.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the mouse LD50 value of 419 mg/kg (EHC 49 (1985)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 value of 1580 mg/kg (RTECS (1997), original literature: National Technical Information Service. (Springfield, VA 22161), formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0545572), the substance was classified as Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant notes, as for the information from the "List 3" information source designated in the GHS classification guidance for the Japanese government, moderate irritation of the substance was reported in the standard Draize test using rabbit (RTECS (1997)), but details were unknown.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Oral administration to mice at 136 mg/kg/day, twice a week for 8 weeks caused neuropathy, and revealed adynamic symptom accompanied by slight behavioral changes containing aggression or wariness, and dysfunction of hind limbs. They also showed both atrophy and a significant reduction in the weight of the testes with histopathological degenerations of the epithelial cells of the seminiferous tubules. Thus, toxic effects on the nervous system and testes were noted (EHC 49 (1985), original literature: Hashimoto, K., Sakamoto, J., & Tani, H, (1981) Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice. Arch. Toxicol., 47: 179 - 189). Here, the converted dose level as that of 90-day study which was calculated from the case of continuous treatment with 136 mg/kg/day for 8 weeks was 83.7 mg/kg/day. Thus, because the exposure amount (twice a week, 8 weeks) in the study was lower than the value, the converted value as that of 90-day study was not exceeded 83.7 mg/kg/day. This means, namely, that the classification could not be applicable to "Not classified" category. The daily dose level in the continuous administration for 8 weeks calculated from the total dose (twice a week for 8 weeks) in this study per capita basis was 38.9 mg/kg/day (converted value as that of 90-day study: 23.9 mg/kg/day). Thus, the exposure dose in this study was considered to be within the range of Category 2 (10 - 100 mg/kg/day) of the guidance values. In conclusion, the substance was classified as Category 2 (nervous system, testis).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information