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GHS Classification Result

Chemical Name：Aluminium tri-sec-butoxide
CAS：2269-22-9

Result：


ID:	22A4132
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Although flash point of the substance is 26 degC (Ullmanns (E) (6th, 2003)), since its flash point reported 26 degC (closed-cap) by Aldrich MSDS (Access on Nov. 2010), it was estimated which is >= 23 degC and <= 60 degC, this substance is classified into Category 3.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	-	-	-	-	No data available.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Although the substance is an organic compound containing metal (Al), there is description that "The substance is easily hydrolyzed producing aluminum hydroxide and 2-butanol" (Ullmanns (E) (6th, 2003)). It was assumed that it produces combustible liquid and a small amount of flammable gas, and, this substance is classified as "Not classified".
13	Oxidizing liquids	Classification not possible	-	-	-	-	Although the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen, due to lack of additional data, classification is not possible.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data were available. The substance is easily hydrolyzed into aluminum hydroxide and 2-butanol (Ullmanns (E), 6th (2003)). [Refer also to classification results of 2-butanol (ID 913).]
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). As relevant information, as for aluminum hydroxide, no maternal toxicity, embryo/fetal toxicity or teratogenicity were reported in the oral study in mice administered during the gestation period (66.5 - 266 mg/kg/day), and no toxic effects were reported in the oral study in mice administered during the gestation period (57.5 mg/kg/day). Reduced fetal body weight and increased skeletal variations were reported in the oral study in rats administered during the gestation period (384 mg/kg/day). It was also reported that in the oral study in rats administered during the gestation period (192 - 768 mg/kg), the NOEL was 768 mg/kg/day (the aforementioned, JECFA FAS 58 (2007)). As for the current classification for 2-buthanol was "In the two-generation reproduction study by drinking water in rats, there was no effect on reproductive potential, only the minimum influence (growth retardation of pups) was observed. On the other hand, in the inhalation study in rats exposed during the gestation period, reduction of live newborns and increase of embryo absorption was observed at the dose in which toxic effects on dams were observed (PATTY, 4th (1994), ACGIH (2002), DFGOT vol.19 (2003)). It was suggested that the substance may have adverse effects on fertility or embryo. The substance was considered as Category 2."
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). No data were available for aluminum hydroxide. While as for the current classification for 2-buthanol, it was described as follows. "Inhalation by high concentration exposure levels to mice caused the symptoms of depression of central nervous system (DFGOT vol.19 (2003)). By inhalation exposure, anesthetic actions were seen in humans and mice (EHC 65 (1987), and in rats and mice (PATTY, 4th (1994), DFGOT, vol.19 (2003)). From the description (ACGIH (2002), DFGOT, vol.19 (2003), Society for Occupational Health, Recommendation of Occupational Exposure (1986)) that nasal and throat were stimulated in humans in high exposure levels, the substance was considered to be respiratory irritant. Thus the substance was concluded as Category 3 (drowsiness and dizziness) and Category 3 (irritation to respiratory organs)."
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). As relevant information on aluminum hydroxide, it was described that this was used as a pharmaceutical drug (antacid), and this might cause constipation, nausea, vomiting as its side effects (Handbook of Japanese Pharmaceutical Drugs (2010), Merck Manual, vol. 18 (2006)). It was also described that through a long-term treatment, this might cause aluminum encephalopathy or aluminum osteopathy (Handbook of Japanese Pharmaceutical Drugs (2010)). As for the animal experiments, no effects were reported on clinical signs, food and water consumption, growth, hematological and serum analyses, tissue and plasma concentrations of aluminum, histopathology in the 28-day oral dose study in rats (converted dose level as that of 90-day study: 407 mg/kg/day) (EHC, 194 (1997)). It was also reported that in the oral dose study in rats (17 - 29 mg/kg/day) the animals showed significant impairment of growth at 3 - 4 weeks of administration, and rachitic changes occurred in the bone (HSDB (2009)). As for the current classification for 2-buthanol, it was written as "No data available. Classification not possible."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）