GHS Classification Result

Chemical Name：Strontium chloride
CAS：10476-85-4

Result：
ID: 22A4120
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - This substance is classified as "Not classified" because it is reported as "Non-combustible solid". (GESTIS (Access on Oct. 2010))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - This substance is classified as "Not classified" because it is reported as "Non-combustible solid". (GESTIS (Access on Oct. 2010))
11 Self-heating substances and mixtures Not classified - - - - This substance is classified as "Not classified" because it is reported as "Non-combustible solid". (GESTIS (Access on Oct. 2010))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (Sr), its water solubility is 54.7 g/100 g H2O (25 degC) (Lide (90th, 2009)) and it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Although the substance is compound containing chlorine which is chemically bonded to the metal (Sr), Strontium is similar to calcium in its chemical reactions (HSDB (2006)), and calcium chloride has no oxidizing properties. Therefore, it was assumed that strontium chloride also has no oxidizing properties.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 value of 2250 mg/kg (CICAD 77 (2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The classification was concluded as Category 2 based on the positive results in the chromosome aberration test using bone marrow obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (ATSDR (2004)). As relevant information, as for in vitro mutagenicity study, negative results in the chromosome aberration test using Chinese hamster oocytes were reported (CICAD 77 (2010)).
6 Carcinogenicity Classification not possible - - - - Insufficient data were available. As relevant information, in the 3-year oral administration study via drinking water in male rats, which had some interpretative limitation for carcinogenicity, no tumors in relation to administration were reported (CICAD 77 (2010)).
7 Reproductive toxicity Classification not possible - - - - In the three-generation oral administration study via drinking water using rats, no effects on reproduction were observed (CICAD 77 (2010)). However, the available information was inadequate to evaluate the effects on fertility (CICAD 77 (2010)). Therefore, the substance was classified as "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In various feeding or drinking studies in rats or mice, the principal findings were the effects on the bones which consisted of stimulation of bone mineralization, excessive osteoid thickness associated with inhibition of the rate of calcification, growth inhibition, irregularly hypertrophy of the epiphyseal growth plate, inhibition of calcification and absorption in metaphysis (IRIS (2002)). These were the findings at the higher dose level beyond the guidance values. In the 9-week drinking study in rats, the NOAEL of 525 mg/kg/day as strontium (converted dose level as that of 90-day study as strontium dichloride: 658 mg/kg/day) was reported (IRIS (2002)). And no histopathological effects were noted up to the dose level over the range of the guidance values (145 mg/kg/day as strontium dichloride) in the 3-month drinking study in rats (IRIS (2002)). Consequently, "Not classified" category was applicable for oral route, however, the classification for specific target organ toxicity (repeated exposure) was determined as "Classification not possible" due to unknown effects in the other routes (no data were available).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" from its 48h-EC50 = 125 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 547 g/L (Initial Risk Assessment Report (NITE, CERI, NEDO), 2010)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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