GHS Classification Result

Chemical Name：Triethyl phosphate
CAS：78-40-0

Result：
ID: 22A4119
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since it is assumed that 115 degC (240 degF) (open-cup) (HSDB (2006)) of flash points is estimated to be >= 93 degC for the closed-cup flash point test methods, The substance is classified as "Not classified".
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Although this substance contains P-O in the molecule, it does not correspond to chemical groups associated with self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 454 degC (HSDB (2006)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although this substance contains the metalloid (P), it is classified as "Not classified" because of the description of "when mixed with water is quite stable at room temperature" (HSDB (2006)).
13 Oxidizing liquids Classification not possible - - - - Although the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen, due to lack of additional data, classification is not possible.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 1131 - 1600 mg/kg (SIDS (Access on Nov. 2010)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 value of > 20 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the rat LC50 value of > 8.817 mg/L (SIDS (Access on Nov. 2010)), the substance was classified as "Not classified". The test concentration was higher than the saturated vapour pressure concentration (3.85 mg/L), criterion values for dusts and mists were adopted.
2 Skin corrosion/irritation Not classified - - - - Moderate irritation was noted in 1 of 3 tested animals in the animal experiment (OECD TG 404, GLP-compliant), but SIDS concluded that the substance was not a skin irritant in accordance with guideline (SIDS (Access on Nov. 2010)). The substance caused slight irritation to guinea pig, but caused non irritation to rabbit (BUA 37 (1989)). Based on these documents, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In the rabbit test, transient conjunctivitis was noted. In other rabbit test, corneal opacity, iritis and corneal coloration were noted (BUA 37 (1989)). Based on these documents, the substance was classified as Category 2. As relevant notes, in Draize tests using rabbits, instillation of 100 mg of substance caused moderate irritation (RTECS (2006), original literature: National Technical Information Service. OTS0528351), which was the "List 3" information source of GHS classification guidance for the Japanese government.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Insufficient data were available. In the sensitization test using guinea pig, no sensitizing effect was reported (BUA 37 (1989)). However, it was the datum from the "List 2" information source designated in the GHS classification guidance for the Japanese government, and there was neither information on test methods nor positive rate.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the dominant lethal test using mice of 2 strains intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells) (BUA 37 (1989)), chromosome aberration test using spermatogonia obtained from mice intraperitoneally administered (in vivo mutagenicity test in germ cells) (BUA 37 (1989)), and chromosome aberration test using bone marrow of mice (in vivo mutagenicity test in somatic cells) (SIDS (Access on Nov. 2010)). As relevant information, as for in vitro studies, negative results in the Ames test (NTB DB (1982)) and HPRT test using V79 cells were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the 2-generation feeding study in rats, which were administered from 92 days before mating to 120 days after mating for males, and to 150 days after mating for females, the litter size was reduced at the dose level (670 mg/kg/day) that did not induce general toxicity to parental animals (SIDS (Access on Nov. 2010)). Therefore, the substance was classified as Category 1B. However, there was a description that this experiment should be considered as a pilot study using few animals that suggested some adverse effects on the reproduction and development of rats (BUA 37 (1989)). Therefore, the substance was concluded as Category 2. As relevant information, the developmental toxicity study in rats showed no evidence of teratogenic potential up to the highest dose of 625 mg/kg/day (SIDS (Access on Nov. 2010)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There was a description stating that this substance was harmful and caused the narcotic effect, and showed obvious neurotoxicity (cholinesterase inhibition) without delayed neurotoxicity (SIDS (Access on Nov. 2010)). In various experiments on acute toxicity the following symptoms of poisoning were observed: narcosis, excitations followed by depression of central nervous system, loss of muscular coordination and quadriplegia, etc. (BUA 37 (1989)). Dogs treated with a single oral dose of 1070 mg/kg revealed lateral position, dyspnea, sedation, narcotic-like condition and twitching, then died on the day of administration. In addition, the other dogs received a single dose of 100 or 250 mg/kg caused sedation and slight tremor with inhibition of plasma cholinesterase (BUA 37 (1989)). As described above, in addition to Category 3 (narcotic effects), the classification was determined as Category 2 (nervous system) because neurotoxic signs occurred in dogs at the dose level equivalent to Category 2 of the guidance values.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The NOAEL in the 28-day oral dose toxicity in rats was reported as 1000 mg/kg/day (converted dose level as that of 90-day study: 311 mg/kg/day) (SIDS (Access on Nov. 2010)). There were no adverse effects up to 5000 ppm (335 mg/kg/day) in the 92-day feeding study in rats, and there were also no serious toxicity at the concentration of 5000 ppm (330 mg/kg/day) in another 9-week feeding study in rats (BUA 37 (1989)). While in the inhalation study exposed 12 times to rats (5 hours/day, 5 days/week) at the concentration of 1.786 mg/L as an aerosol (converted concentration as that of 90-day study: 0.275 mg/L), lethargy, reduced sensitivity to noise, behavioral disturbances, etc. were observed, however, hematological and biochemical parameters were within the ranges of the control group and no pathological changes were determined macroscopically or microscopically (BUA 37 (1989)). Thus, no adverse effects were shown up to the doses beyond the guidance values in both oral and inhalation routes, which led to a conclusion as "Not classified". However, since data for inhalation route were provided from the "List 2" information source designated in the GHS classification guidance for the Japanese government and the effects in dermal route was unknown due to no information, the classification for specific target organ toxicity (repeated exposure) was determined as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" since its toxicity to algae (Scenedesmus subspicatus) and crustacea (Daphnia magna) are > 100 mg/L (SIDS, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility: 500000 mg/L (SRC, 2009)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information