GHS Classification Result

Chemical Name：Trimethylthiourea
CAS：2489-77-2

Result：
ID: 22A4099
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 316 mg/kg bw (RTECS (2008), original literature: Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) NCI-E-C-72-3252, (1973)), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 based on the document that the substance was considered as a sensitizer since the substance was thiourea derivative and the patient sensitized to ethyl(butyl)thiourea also reacted to this substance (Contact Dermatitis, Frosch, 4th, (2006)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and the chromosome aberration test using CHO cells, positive results in the gene mutation test using mouse lymphoma cells, were reported (NTP DB (Access on Oct. 2010)).
6 Carcinogenicity Classification not possible - - - - In the examination after 29-week or 14-week observation period following 77-week oral administration in rats or mice, respectively, significant increase in the incidence of follicular cell carcinomas/adenomas of the thyroid was found in the high dose group with dose-dependency (control group 0/20, low-dose group 1/50, middle-dose group 1/50, high-dose group 14/50), thus, this substance was carcinogenic in female rats (NTP TR 129 (1979)). However, in the same study, there was not sufficient evidence for the carcinogenicity of the substance in male rats or in mice of either sex (NTP TR 129 (1979)). Accordingly, the classification was concluded as "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 77-week feeding studies in rats and mice, except for suppression of body weight gain in female rats and mice in both sexes, no significant differences were shown in clinical signs of toxicity, mortalities, or incidences of nonneoplastic lesions in the treatment groups up to the high dose level of 500 ppm (25 mg/kg/day) in rats as well as up to the high dose group at 1000 ppm (150 mg/kg/day) in mice compared with those of controls (NTP TR 129 (1979)). Thus, since no toxic effects were seen in mice up to the dose at 150 mg/kg/day, which over the range of the upper limit of the guidance values, the classification was concluded as "Not classified" category in oral route. However, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible" due to no information with regard to the other routes. As relevant information, the results of the 4-week feeding studies in rats and mice (NTP TR 129 (1979)), conducted as preliminary tests for the above studies, were excluded from available information to classify because of lack of sufficient examination items for assessment.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" from its 48h-LC50 = 770 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 13990 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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