GHS Classification Result

Chemical Name:2-Methylimidazole
CAS:693-98-1

Result:
ID: 22A4091
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the mouse LD50 values of 1400 mg/kg (NTP TOX67 (2004)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The classification was concluded as "Category 2" based on the positive results in the micronucleus test using peripheral blood obtained from mice by the dietary administration for 14 weeks (in vivo mutagenicity test in somatic cells) (NTP TR 516 (2004)). As relevant information, negative results in the micronucleus test using bone marrow obtained from rats and mice single intraperitoneally administered (in vivo mutagenicity test in somatic cells) (NTP DB (Access on Sep. 2010)). And as for in vitro study, negative in the Ames test (NTP DB (Access on Sep. 2010)) were reported.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the 2-year dietary administration study in rats, it was concluded to be a certain evidence of carcinogenicity in males and a clear evidence in females from the data on increased incidence of follicular cell neoplasms in the thyroid (NTP TR 516 (2004)). In the 2-year dietary administration study in mice, it was concluded to be a certain evidence of carcinogenicity in males and females from the data on increased incidence of follicular cell adenomas in the thyroid and hepatocellular neoplasms in male, and from the data on increased incidence of hepatocellular neoplasms in females (NTP TR 516 (2004)). From the conclusion of the above data in 2-year oral administration studies in rats and mice, limited evidence of carcinogenicity in the two species of animals was suggested, and carcinogenicity in humans was suspected. Therefore, the classification was concluded as Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was reported that the animals exposed to the substance exhibited convulsant activity containing restlessness and paralysis, etc. (NTP TOX 067 (2004)) and that the substance induced acute neurologic effects in mice by oral administration, 50% occurrence dose of convulsion was 1300 mg/kg (NTP TOX 067 (2004)). Based on the information, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid, hematopoietic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (thyroid, hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the 14-week feeding study in rats, the incidences of follicular cell hyperplasia of the thyroid gland were significantly increased in both sexes, especially in males the changes were significantly increased at the dose level of 1250 ppm (80 mg/kg/day: equivalent to Category 2 of the guidance values) or higher (NTP TOX 67 (2004)). The effect on the thyroid gland may be caused by rodent-specific UDP-GT induction or alterations of thyroid hormone values. However, there was no description with regard to the relevancy, the effects on humans could not deny. Therefore, the substance was classified as Category 2 (thyroid gland). Similarly, in the 14-week feeding study in mice, the significant increase in the incidences of follicular cell hypertrophy of the thyroid gland was also reported (NTP TOX 67 (2004)). In addition, in the 2-year feeding study in mice, the incidence of hematopoietic cell proliferation in the spleen was significantly increased in all exposed groups (75 mg/kg/day or higher) in males and at 325 mg/kg/day in females, and the incidence of pigmentation was significantly increased in all exposed groups (75 mg/kg/day or higher) in males and in groups at 150 mg/kg/day or higher in females (NTP TR 516 (2004)). These results revealed that the effects were seen in the dose levels equivalent to Category 2 of the guidance values in males, and that macrocytic, normochromic to hypochromic anemia indicated in the hematology, and significant increase in incidences of hyperplasia of bone marrow and pigmentation in renal proximal tubule were also noted (NTP TR 516 (2004)). Therefore, the substance was additionally classified as Category 2 (hematopoietic system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Classified as "Not classified" from its 48h-EC50 = 200 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2006).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility: 80850 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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