GHS Classification Result

Chemical Name：o-Nitrophenol
CAS：88-75-5

Result：
ID: 22A4085
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although it contains chemical groups (N-O) associated with explosive properties in the molecule, the substance is rated as Division 6.1(III) by UNRTDG (UN1663), and it does not correspond to the explosive of a higher rank.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Type G - - - - Although it contains chemical groups (N-O) associated with explosive properties in the molecule, the substance is rated as Division 6.1(III) by UNRTDG (UN1663), and it was estimated that the substance was classified into Type G.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is 485 degC (Hommel (1996)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen. Since no test results are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - This substance is a solid whose melting point is lower than 55 degC, since no test results are available, classification is not possible.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 value of 2830 mg/kg bw (ATSDR (1992)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 value of > 5000 mg/kg bw (CICAD 20 (2000)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test (OECD TG 404), slightly irritating was reported (CICAD 20 (2000)). In another rabbit test, application of 50 mg of test substance for 24 hours caused slightly irritating and irritation index was 1.4/8.0 (IUCLID (2000)). Based on these documents, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).
3 Serious eye damage/eye irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not irritating" resulted from rabbit test (OECD TG 405) (CICAD 20 (2000)). As relevant notes, in another rabbit test in which 30 mg of the test substance was applied, the substance was concluded to be a slight irritant, but the irritation index was under 15 (10.8/110) (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified as "Not classified" based on the documented case of "no skin-sensitizing effects" from Buehler test using guinea pig (OECD TG 406) (CICAD 20 (2000)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro mutagenicity test, negative results in the Ames test were reported (NTP DB (Access on Aug. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the oral administration study using pregnant rats during the organogenetic period, slight but statistically significant increase in post-implantation losses and early resorption was observed at the dose levels at which transient, but dose-dependent decrease in body weight gain was observed in maternal animals (CICAD 20 (2000)). Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (blood) Danger H370: Causes damage to organs (blood) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There was a description that aromatic amine compounds were generally known to cause methemoglobinemia in both humans and the experimental animals (ATSDR (2000)). In cats, the oral application of this substance at the doses ranging from 50 to 250 mg/kg resulted in a dose-dependent formation of methemoglobin (CICAD 20 (2000)). Since judging from the guidance values, the effective dose corresponded to Category 1, the substance was classified as Category 1 (blood). As relevant information, in the acute oral toxicity studies in rats and mice (LD50 values: 2830 - 5376 mg/kg bw for rats, 1300 - 2080 mg/kg bw for mice), clinical signs observed after treatment included dyspnea, ataxic gait, trembling, somnolence, apathy, and cramps. As for macroscopic findings, congestion in the liver and kidneys and ulcers in the stomach in high-dose rats (CICAD 20 (2000)). In the case of mice, although it was reported that clinical signs were observed at the dose levels of Category 2 of the guidance values and higher, the detail of both findings and dose levels was indistinct. (CICAD 20 (2000)). In addition, it was also reported that there were chiefly two patterns for methemoglobin formation, and rat/mouse/rabbit/guinea pig/monkey was less sensitive to methemoglobin formation and they generally could reduce induced methemoglobin more effectively than human/dog/cat (Blom, 2000). The cat was the most sensitive to methemoglobin formation, primarily because of different type of hemoglobin (EU-RAR Vol. 65 (2006)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 28-day repeated dose oral study in rats (OECD TG 407), no treatment-related changes were observed in histopathology for the main organs, and no significant toxic findings were noted up to the high dose level of 200 mg/kg/day (converted dose level as that of 90-day study: 62.2 mg/kg/day) except for the organ weight change of the adrenal glands (CICAD 20 (2000)). Moreover, in the 4-week inhalation study exposed to rats as vapors, no treatment-related effects in histopathology were detected except for squamous metaplasia of the epithelium lining the maxilloturbinates and nasoturbinates in the high dose group at 60 mg/m3 (converted value as that of 90-day study: 0.018 mg/L). In this study, no obvious effect was noted in the methemoglobin concentration determined after the 11th exposure (CICAD 20 (2000)). The results described above were obtained at the doses within the range of the guidance value. The effects in the dose near the upper limit of the guidance values were unknown. Therefore, the classification was concluded as "Classification not possible" due to insufficient data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 72h-ErC50 = 6.0 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2008).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (14d-BOD degradation rate = 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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