GHS Classification Result

Chemical Name：Diethylene glycol diethyl ether
CAS：112-36-7

Result：
ID: 22A4073
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 71 degC (closed-cup) (ICSC (2004)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 174 degC (ICSC (2004)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 value of 4970 mg/kg (ECETOC TR No.95 (2005)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data were available. As relevant information, as for the data from the "List 3" information source designated in the GHS classification guidance for the Japanese government, the rabbit LD50 value of 6700 microL/kg (6070 mg/kg) was documented (RTECS (2008)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2A based on the documented case of "moderate irritation" (ECETOC TR 95 (2005)) resulted from the test in which 50 mg of the test substance was instilled to the rabbits' eyes.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results were reported in the Ames test (NTB DB (Access on July 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the oral administration study using rabbits during the organogenetic period, clinical signs of dams were observed with most severity in the high dose group (400 mg/kg) . However, there was no effect of treatment on embryo viability. The incidences of resorption and fetal deaths were similar among the treatment group, and there was no influence in other developmental indices either. In addition, embryo/fetal morphogenesis was not observably altered in the findings of external, visceral and skeletal examinations of fetuses (NTP TER 87060 (1987)). In addition, in the oral administered study using mice during the organogenetic period, mortality of dams increased with the rise of the dosage, but there were no effects of treatment on developmental indices. The incidence of major malformations was low in all groups and was not dose dependent (NTP TER 86059 (1987)). As stated above, there were no adverse effects on development of offspring, however, effects on sexual functions and fertility of parental animal were unknown, therefore the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 17-day inhalation study in mice exposed to saturated vapors at 400 ppm/17hrs/day (converted concentration as that of 90-day study with 6hrs/day exposure basis: 0.844 mg/L/6hrs), restlessness was observed as the only clinical sign in spite of no remarkable findings at necropsy (ECETOC TR95 (2005)). However no further information was provided, and the classification was not possible due to lack of sufficient data. As relevant information, as the results of the studies administered to pregnant animals during the organogenetic period, signs of toxicity such as ataxia, coma, dyspnea appeared in the rabbits treated at 400 mg/kg/day for 14 days (converted dose level as that of 90-day study: 62.2 mg/kg/day) (NTP TER 87060 (1987)), and in the mice study, highly sensitive of the function of central nervous system occurred and clinical signs such as ataxia, coma and lethargy were observed in most of the animals treated at 300 - 4500 mg/kg/day for 10 days (converted dose level as that of 90-day study: 33.3 mg/kg/day or higher) (NTP TER 86059 (1987)). Although these results suggested the effect on central nervous system, these were not adopted as the basis of classification because these studies was conducted using pregnant animals and with short-term treatment period.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" from its 96h-LC50 > 100 mg/L for fish (Alburnus alburnus) and crustacea (Nitocra spinipes) (HSDB, 2007).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 1000 g/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information