GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Copper(II) acetate (anhydrous)
CAS：142-71-2
Result：
| ID: | 22A4072 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not flammable (Weiss (2nd, 1986)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not flammable (Weiss (2nd, 1986)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not flammable (Weiss (2nd, 1986)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it contains a metal (Cu), its water solubility is 8.11E+005 mg/L (SRC Phys Prop (Access on July 2010)) and it is considered that the substance doesn't react strongly with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 value of 595 mg/kg bw (EHC 200 (1998)), the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data were available. As relevant information, the substance was classified as "Group 2" as copper and its compounds by Japan Society for Occupational Health, but individual substances within the group that have the sensitization potential were not identified (Recommendations of Occupational Exposure Limits (2009)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | There was an oral test in which the substance was administered to rats via drinking water from seven weeks before mating to the gestation period (the date of end of administration was unknown), and fetuses were examined at the day of 12 and 22 of gestation and after delivery. There were no overt signs of toxicity in the treated maternal rats. As for fetuses, only slight effects such as reduction of crown-rump length and somite number, and delayed ossification were observed. Neither the number of litter, nor body weight was different from the control group, and no serious effects on the exterior and a visceral malformation were observed (EHC 200 (1998)). However, there was no reference about the exposure to sires, and no information was provided regarding sexual functions and fertility of parental animals. Therefore, the substance was classified as "Classification not possible" due to lack of sufficient data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (liver, kidney, blood), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (liver, kidney, blood) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
No data were available for this substance, but the following was information on soluble copper compounds. According to the case reports of ingestion of a large amount of compounds by suicide attempt or accident, clinical signs observed included epigastric pain, headache, nausea, dizziness, vomiting, diarrhea, tachycardia, tachypnea and dyspnea were observed (EHC 200 (1998), PIM G002 (1999)). And it was reported that liver damage (jaundice, elevation of serum transaminase and serum bilirubin levels, enlargement, centrilobular necrosis and cholestasis), renal dysfunction (elevated blood urea nitrogen and urobilinogen levels, proteinuria, anuria and oliguria), and methaemoglobinemia, hemolytic anemia and cyanosis were observed (PIM G002 (1999)). Based on these findings, the substance was classified as Category 1 (liver, kidney, blood). Furthermore, it was described that exposure to copper fumes cause sneezing, coughing and discomfort of gastrointestinal tract (PIM G002 (1999)), and that inhalation of dust cause irritation of throat and lung (HSDB (2009)). Thereby Category 3 (respiratory tract irritation) was added. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In the 105-day feeding study in rabbits, the effects on the liver (pigment deposition, necrosis and cirrhosis) were reported at dietary levels between 97 to 2370 ppm (dose levels: approx. 2.9 - 71 mg/kg/day) (JECFA 17 (1982)). Moreover, as the effect on humans, there were case reports of liver failure following chronic ingestion of drinking-water containing high copper concentrations (EHC 200 (1998)), and a case of jaundice and hepatomegaly following 3-year oral intake of copper supplement (ATSDR (2004)). Therefore, the substance was classified as Category 1 (liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 96h-LC50 = 0.39 mg/L for fish (Pimephales promelas) (HSDB, 2009). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and data on rapid degradation are not available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |