GHS Classification Result

Chemical Name：Dipropylene glycol methyl ether
CAS：34590-94-8

Result：
ID: 22A4063
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 79 degC (closed-cup) (BUA 174 (1995)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 270 degC (SIDS (2001)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Three LD50 values for rats of 5230 mg/kg, 5180 mg/kg and 5400 mg/kg were reported (SIDS (2001)), and all data exceeded 5000 mg/kg bw. Therefore, the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Three LD50 values for rabbits of 13000 - 14000 mg/kg, > 19000 mg/kg and 9500 mg/kg were reported (SIDS (2001)), and all data exceeded 5000 mg/kg. Therefore, the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - According to the result that the 7-hour exposure to rats at 500 ppm (3.1 mg/L) caused no mortality (SIDS (2001)), converted LC50 value as that of 4-hour exposure was considered to be over 661 ppm (4.1 mg/L). However, because the category could not be specified, the substance was classified as "Classification not possible". As for the test substance, in the evaluation document (SIDS (2001)), there was an information that the test substance was saturated vapor (fog) atmosphere. Therefore, it was judged that the substance was vapor mixed with mist, and the criterion values for vapor were adopted for classification.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Several studies using rabbits were reported that the substance was not a skin irritant (SIDS (2001)). In the human case, because the result of no irritating was reported by application of the undiluted substance to the skin for 5 days (SIDS (2001)), it was concluded that the substance was not a skin irritant (SIDS (2001)). Based on the information, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In the rabbit test, instillation of 0.1 mL of undiluted test substance caused irritation to the conjunctiva and eyelid. These effects recovered within 7 days. As additional findings, it was also reported that slight effect of the anterior epithelium of the cornea was observed (SIDS (2001)). Based on the document, the substance was classified as Category 2B. As relevant notes, in another rabbit test, instillation of 500 mg of test substance caused no irritation (SIDS (2001)). Application of 20% aqueous solution to eyes of ten male volunteers produced slight stabbing pain, lacrimation and mild hyperemia of the conjunctiva (ECETOC TR95 (2005)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified as "Not classified" based on the documented case that no sensitization was reported in the skin sensitization test for 200 human subjects with application to their dorsal skin, and the substance was concluded as not skin sensitizer (SIDS (2001)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo data. As relevant information, as for in vitro studies, negative results in the Ames test and the chromosome aberration test using CHL cells were reported (SIDS (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the inhalation studies using pregnant rats or rabbits during the organogenetic period, both animal species didn't show the embryotoxicity or teratogenicity in the highest concentration of 300 ppm, which was realizable to expose under standard temperature and pressure, and the adverse influence was not observed in the development of offspring (SIDS (2001)). However, since no information was provided regarding sexual functions and fertility of parent animals, the classification was not possible.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Depression of central nervous system was observed in rats by oral administration, and a mild narcosis was seen in rats exposed by inhalation for 7 hours (SIDS (2001)). In addition, the transient narcotic effect was also reported in rabbits by the dermal application (SIDS (2001)). Therefore, the substance was classified as Category 3 (narcotic effects). Furthermore, it was reported that the substance cause slight irritation in the nose in humans and it was also referred to the probable minimum concentrations of irritating to the throat and respiratory tract (SIDS (2001)). It was also reported that, at the concentration above 100 ppm, torment by irritation of nose, throat or respiratory tract occurred prior to the first signs of CNS impairments (ACGIH (2001)). Based on these descriptions, the substance was classified as Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the 4-week oral study in rats, transient salivation and liver effects (significant increase in liver weight and centrilobular hypertrophy) were observed in the high dose group at 1000 mg/kg/day (converted dose level as that of 90-day study: 308 mg/kg/day). However, no other treatment-related effects were reported (SIDS (2001)). Because the liver effects found in the study were concluded to be adaptive changes (SIDS (2001)), it was considered that no adverse effects were seen up to the highest dose beyond the range of the guidance values. Thus, the classification was considered as equivalent to "Not classified" for oral route. Furthermore, it was reported that the NOEL in the 4-week dermal application study in rats was 1000 mg/kg/day (converted dose level as that of 90-day study: 308 mg/kg/day), and that NOEL in the 90-day dermal application in rabbits was 2850 mg/kg/day (SIDS (2001)). Both of which were over the range of guidance values. Furthermore, the NOELs in the 13-week inhalation studies in rats or rabbits (as vapors, 6 hours/day, 5 days/week) were reported as 200 ppm (1.212 mg/L) or higher in each study (SIDS (2001)), and these were over the upper limit of the guidance values. Thus, the classification for each route via dermal and inhalation was also equivalence to "Not classified" category. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Not classified".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" since all LC50 and EC50 values exceeded 100 mg/L in acute toxicity tests for fish, crustacea and algae (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 1000000 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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