GHS Classification Result

Chemical Name：Dimethyl phosphite
CAS：868-85-9

Result：
ID: 22A4050
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 64 degC (closed-cup) (Ullmanns (E) (2003)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Although there are chemical groups (P-O) present in the molecule associated with explosive or self-reactive properties, due to lack of additional data, classification is not possible.
9 Pyrophoric liquids Not classified - - - - Since its auto ignition point is 237 degC (ICSC (2005)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metalloid (P), its water solubility is > 10 g/100 mL (HSDB (2007)) and it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Classification not possible - - - - Although this substance is an organic compound containing oxygen which is chemically bonded to P, other than carbon or hydrogen, due to lack of additional data, classification is not possible.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of 3040 (male) and 3283 (female) mg/kg (OECD TG401) (SIDS (2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The rabbit LD50 values of 681 mg/kg and 2400 mg/kg were documented (SIDS (2010)), and each of the data are equivalent to Category 3 and "Not classified" category in the JIS classification (corresponding to Category 5 in the UN-GHS classification) respectively. Selecting the greater hazard category, the substance was classified as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Although it was documented that the inhalation of 7.1 mg/L/6hrs (converted value as that of 4-hour exposure: 9 mg/L) for rats caused no mortality (SIDS (2010)), the datum did not provide a basis for the classification, the classification was not possible. For further information, the test concentration (7.1 mg/L) was higher than 90 % of the saturated vapor pressure concentration (26.8 mg/L), the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "slightly irritating" (SIDS (2010)) resulted from the 4-hour rabbit test with 0.5 ml of the substance. As relevant notes, long term and repeated exposure of the substance caused moderate to severe irritation to the skin and mucous membrane of rabbit (SIDS (2010)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In the rabbit test (equivalent to OECD TG405), mild to moderate edema were observed after 1 and 4 hours of applications and these symptoms recovered on day 5 - 7 (SIDS (2010)). Based on the document, the substance was classified as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2 based on the positive results in the micronucleus test and the chromosome aberration test using bone marrow cells of mice by intraperitoneal administration (in vivo mutagenicity test in somatic cells) (SIDS (2010)). As relevant information, as for in vitro mutagenicity studies, positive results in the Ames test at 5 - 10 mg, the mouse lymphoma assay and the chromosomal aberration test using CHO cells, were reported (SIDS (2010)).
6 Carcinogenicity Classification not possible - - - - The substance was classified as "Classification not possible" based on the criterion of "Group 3" by the IARC carcinogenicity assessment (IARC 71 (1999)). As relevant information, in the 2-year oral carcinogenicity studies of rats and mice, increased incidences of adenoma and carcinoma of alveolar/bronchi, squamous carcinoma of lung and tumors of forestomach were observed in both sexes of rats, however, the tumors were not observed in both sexes of mice (NTP TR287 (1985)).
7 Reproductive toxicity Classification not possible - - - - The classification was not possible due to lack of sufficient data. In the reproductive and developmental toxicity screening tests using rats (OECD TG 421), severe general toxic effects and effects on reproductive function and fertility were observed in both sexes. However, because the mortality of maternal animals increased and all female animals died (2/12 males died) (SIDS (2010)), this data was not used for evaluation.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute dermal toxicity study with rabbits, decrease in locomotor activity, ptosis, dyspnea, ataxia and inanimation were noted at 1000 mg/kg, equivalent to Category 2 of guidance values (SIDS (2010)). It was difficult to identify the target organ(s) so that the substance was classified as Category 2 (systemic toxicity). As relevant information, in the acute inhalation study, no deaths occurred in both rats and mice, and labored respiration and ptosis were observed only in two of ten mice at concentration of 7 mg/L/6hrs (9 mg/L/4hrs) (SIDS (2010)). Furthermore, clinical signs such as inactivity, weakness, prostration and shallow breathing were observed at doses over the range of the guidance values in the acute oral toxicity studies in rats and mice (SIDS (2010)).
9 Specific target organ toxicity - Repeated exposure Category 1 (eye, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (eye, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 4-week inhalation study in rats (as vapor, 6 hours/day), deaths occurred at 0.483 mg/L or higher, irritation of superficial ocular structures, mucosal irritation and keratitis found at all concentrations, and these findings progressed to cataracts at concentrations more than 0.142 mg/L (converted dose level as that of 90-day study: 0.044 mg/L). Concurrently, skin irritation was also observed at 0.142 mg/L or higher, and these progressed to dermatitis at concentrations more than 0.483 mg/L (converted dose level as that of 90-day study: 0.149 mg/L). It was documented that the cause of death was attributed to necrosis and acute purulent inflammation of the skin (SIDS (2010)). In addition, repeated inhalation exposure produced cataracts and progression to necrosis and acute purulent inflammation of the skin that led to death at concentrations corresponding to Category 1. Thus, because it was considered that these severe symptoms were not caused by local effect only, the substance was, therefore, classified as Category 1 (eyes, skin). Besides, in the 13-week oral toxicity studies in both rats and mice, at high doses which exceeded the guidance values, eye changes (degeneration of the lens and keratitis) and lung lesions (inflammation, congestion and histiocytosis) were found in rats, while cardiac mineralization, hepatocellular vacuolization and congestion of the lung were observed in mice (SIDS (2010)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-EC50 = 25 mg/L for crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (28d-BOD degradation rate: 48% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1997)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information