GHS Classification Result

Chemical Name:7-Methyl-3-methylene-1,6-octadiene
CAS:123-35-3

Result:
ID: 22A4041
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point reported ca. 32 degC (closed-cup) (IUCLID (2000)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Although there are chemical groups (unsaturated bonds) present in the molecule associated with self-reactive properties, classification is not possible due to lack of sufficient data.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 value of > 5000 mg/kg bw (JECFA WHO FOOD ADDITIVES SEREIS 54 (2006)), the substance was classified as "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 value of > 5000 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was reported that the substance caused dermatitis to human skin (NTP TR557 (2009)), and in the rabbit test, exposure of the undiluted substance for 24 hours caused moderately irritating (IUCLID (2000)). Based on these documents, the substance was classified as Category 2. As relevant notes, occlusive application of 4% in petrolatum for 48 hours caused no irritation to human skin (IUCLID (2000)).
3 Serious eye damage/eye irritation Classification not possible - - - - It was documented that the exposure to the substance induced conjunctivitis of human eyes (NTP TR557 (2009)), but there were not further details. Thus, the substance was classified as "Classification not possible".
4 Respiratory sensitization Classification not possible - - - - Insufficient data were available. Exposure to the substance induced asthma-like symptoms in human (NTP TR557 (2009)). A 28-year-old man employed as a brewery inspector was presented with respiratory hypersensitivity reaction to the substance in hop (HSDB (2003)). However, it was the only one case report available and it was not concluded to be positive in the evaluation document from the "List 1" information source designated in the GHS classification guidance for the Japanese government, thus the substance was classified as "Classification not possible".
4 Skin sensitization Classification not possible - - - - In the maximization test in humans, using 4% formulation in petrolatum caused no sensitization in 25 volunteers (IUCLID (2000)). However, since it was the information from the "List 2" information source designated in the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in both of chromosome aberration test using bone marrow of rats after single oral administration (in vivo mutagenicity test in somatic cells) and the micronucleus test using peripheral blood erythrocytes by 90-day oral administration to mice (in vivo mutagenicity test in somatic cells) (JECFA WHO FOOD ADDITIVES SERIES 54 (2006)). As relevant information, as for in vitro studies, negative results in the Ames test (NTP TR557 (2009)), the chromosome aberration test with human lymphocytes (JECFA WHO FOOD ADDITIVES SERIES 54 (2006)) and the gene mutation test using Chinese hamster V79 cells (JECFA WHO FOOD ADDITIVES SERIES 54 (2006)) were reported.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In both tests that were orally administered to rats and mice for 2 years, a significant increase in the incidence of renal tubule neoplasms in male rats and a significant increase in the incidence of hepatocellular neoplasms especially in male mice was observed respectively. Therefore, it was concluded that there were apparent evidences of carcinogenicity in both male rats and male mice (NTP TR557 (2009)). The substance was classified as Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the one-generation reproduction test using rats that were orally administered prior to mating, there were no effects in mating and pregnancy index, however, significant increase in the number of resorptions and subsequent decrease in the number of live fetuses per implantation site were observed, as well as a significant increase in the number of fetuses with skeletal malformations at the dose causing general toxicity (increases in weights of the liver and kidney) to parent animals (JECFA WHO FOOD ADDITIVES SEREIS 54 (2006)). In the developmental toxicity study using pregnant rats that were orally administrated during the organogenetic period, reduced numbers of implantation sites and live fetuses, and increased incidences of fetuses with delayed ossification and other skeletal malformations were observed at the doses that decreased weight gain was observed in dams (JECFA WHO FOOD ADDITIVES SEREIS 54 (2006)). In the perinatal and postnatal study using rats that were orally administered to the substance from day 15 of gestation until postnatal day 21, increase in the number of stillbirth and death, especially during the first week after birth were observed, at the dose which decreased weight gain was observed in dams (JECFA WHO FOOD ADDITIVES SEREIS 54 (2006)). Based on the above, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The results of 14-week oral toxicity study (dose levels: 0, 0.25, 0.5, 1, 2 and 4 g/kg bw/day) and subsequent 2-year oral toxicity studies (dose levels: 0, 0.25, 0.5 and 1 g/kg bw/day) in rats and mice were available. It was reported that deaths occurred in higher dose groups accompanied by various effects containing those in the liver and kidneys in the treatment groups in each study (NTP TR557 (2009)). As the effects of them observed at the lower doses of them, significantly increased incidence of renal tubular necrosis was observed in all treatment groups of both sexes in a 14-week oral study in rats, and the incidence of nephrosis (degeneration of the epithelium of renal tubular ) was markedly increased in all treatment groups of both sexes in a 2-year oral study in rats. However, the doses in each study exceeded the range of the guidance values, and the effects at the upper limit of the guidance values were unknown, which led to the conclusion as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 48h-EC50 = 0.45 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is suspected to be bioaccumulative (LogPow = 4.17 (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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