GHS Classification Result

Chemical Name：Oct-1-ene; 1-Octene
CAS：111-66-0

Result：
ID: 22A4039
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 8 degC (closed-cup) (Bretherick (7th, 2007)) is > 23 degC, and initial boiling point reported 121 degC (Merck (14th, 2006)) is > 35 degC, the substance corresponds to Category 2.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Although there are chemical groups (an unsaturated bond (olefins)) present in the molecule associated with self-reactive properties, classification is not possible due to lack of sufficient data.
9 Pyrophoric liquids Not classified - - - - Since its auto ignition point is 250 degC (Hommel (1996)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 value of > 5000 mg/kg bw (GLP-compliant) (SIDS (2000)), the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - Although the rabbit LD50 value of > 1430 mg/kg bw (GLP-compliant) was documented (SIDS (2000)). However, because this data did not allow for the determination of the classification, the classification was not possible.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the rat LC50 value of 8050 ppm/4hrs (SIDS (2000)), the substance was classified as Category 4. The test concentration (6050 - 11580 ppm) was less than the 90% of the saturated vapor pressure concentration (20605.2 ppmV), the criterion values for gas were adopted for the classification.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In the rabbit test (OECD TG404, GLP-compliant), exposure of the substance caused well-defined erythema and slight to severe edema, but these signs recovered by day 7. However, desquamation and crust formation were noted, and the Draize PII (primary irritation index) was 3.42 on a scale of 8 (SIDS (2000)), thus the substance was classified as Category 2.
3 Serious eye damage/eye irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not irritating" (SIDS (2000)) resulted from the rabbit test (FHSA method, GLP-compliant) in which average Draize score (maximum score was 110) were 3 at one hour after administration, 0.3 at 24 hours and 0 thereafter. In other rabbit test (FHSA method), the substance was also reported as not irritating (SIDS (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not sensitizing" resulted from the Buehler test (OECD TG406, GLP-compliant) using 5 guinea pigs in which induction of sensitization was not seen in all examination animals (SIDS (2000)).
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo data. As relevant information, as for in vitro studies, negative results in the Ames test (SIDS (2000), NTP DB (Access on Jun. 2010)) and negative results in the chromosome aberration test using hamster ovary cells (SIDS (2000)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was reported that repeated skin contact with alkenes (C6-C12) might cause dryness of skin, and inhalation might cause effects on the central nervous system. Since it was described that signs and symptoms of CNS depression such as headache, dizziness, or loss of appetite could completely recover by interruption of exposure (SIDS (2000)). Thus, the substance was classified as Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 90-day gavage study with rats (dose levels: 0, 5, 50 and 500 mg/kg/day), no remarkable changes were seen in body weight, food consumption, clinical signs, hematology, and necropsy findings. In the high dose group (500 mg/kg/day), increased kidney weights and decreased plasma chloride in both sexes, unspecified renal histopathological changes in males, increased plasma creatinine concentration in females were observed as slight changes from the control group (SIDS (2000)). However, no serious effects were seen even at the dose level over the range within Category 2 of the guidance values, which led to the classification as "Not classified" when administered via oral route. While no data given in the routes via dermal or inhalation, so the classification was not possible.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From the fact that this substance is a hydrocarbon which coefficient of kinematic viscosity 0.688 mm2/s (20 degrees centigrade) (coefficient of viscosity 0.492 cP (SIDS (2000)) and density 0.7149 g/cm3 (Lide (90th,2009)), the substance was classified as Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 > 3.2, < 10 mg/L for fish (Brachiodanio Rerio) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and there are no adequate data on rapid degradation.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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