Chemical Name:Octan-3-one; Ethyl amyl ketone
CAS:106-68-3
ID: | 22A4036 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2010 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 | Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 46 degC (closed-cup) (Lange (16th, 2005)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. In addition, it is rated as Class 3 PGIII (UN2271) by the UNRTDG. | |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its auto ignition point is 330 degC (GESTIS (Access on June. 2010)), it is considered that the substance does not ignite at room temperature. |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 value of > 5000 mg/kg (PATTY, 5th (2001)), the substance was classified as "Not classified". |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 value of > 5000 mg/kg (PATTY, 5th (2001)), the substance was classified as "Not classified". |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
The substance was classified as Category 2 based on the documented case of "moderate irritation" resulted from rabbit test under an occlusive condition by a wrap with the undiluted substance (PATTY, 5th (2001)). | |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Not classified | - | - | - | - | In the maximization test in humans, using 2% formulation in petrolatum caused no skin sensitization in 25 volunteers (PATTY, 5th (2001)), and in the modified Draize test using guinea pig, the substance caused no sensitization reactions (PATTY, 5th (2001)). Since both were the data from the "List 1" information source designated in the GHS classification guidance for the Japanese government, the substance was classified as "Not classified". |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the HPRT gene mutation test using Chinese hamster V79 cells and micronucleus test were reported (KemI-Riskline (2006)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | As a precaution of clinical signs through an exposure, CNS depression was described in high concentrations (HSDB (2008)). However, since no concrete data were given, the substance was classified as "Classification not possible". |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. |
10 | Aspiration hazard | Classification not possible | - | - | - | - | The substance is liquid and has a coefficient of kinematic viscosity of 0.97 mm2/s calculated from the coefficient of viscosity of 0.8 mPa*s at 20 degrees centigrade (GESTIS (Access on Jun. 2010)). Because it is not a hydrocarbon but a ketone, the substance was classified as "Classification not possible". |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |