GHS Classification Result

Chemical Name:p-Tolylaldehyde
CAS:104-87-0

Result:
ID: 22A4035
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point reported 71.5 degC (closed-cup) (GESTIS (Access on June 2010)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its auto ignition point is 395 degC (GESTIS (Access on June. 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 1600 mg/kg (PATTY, 5th (2001)), the substance was classified as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data were available. Although the rat LD50 value of 2500 mg/kg (RTECS (2000)) was documented, the details were not provided.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Although the rat LC50 value of > 2.2 mg/L/6hrs (converted value as that of 4-hour exposure: > 3.3 mg/L/4hrs) was documented (PATTY, 5th (2001)), the classification was not possible because class could not be determined from only this value. Therefore, the substance was classified as "Classification not possible". The test concentration (2.2 mg/L) was higher than the saturated vapor pressure concentration (1.61 mg/L), the criterion values for dust/mist were adopted for the classification.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In the rabbit test, moderate irritation was reported (PATTY, 5th (2001)). And in guinea pig test, occlusive exposure of the substance for 24 hours caused moderate irritation with edema, erythema, and scattered necrosis (HSDB (2009)). Based on these documents, the substance was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In the rabbit test, moderate irritation was reported (PATTY, 5th (2001)). In the other rabbit study, the substance caused moderate irritation consisting of iritis in 2 of 3 animals and slight eye irritation in 1 animal. Based on these documents, the substance was classified as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Insufficient data were available. In the standardized skin sensitization test using guinea pigs, the test substance did not show sensitization (HSDB (2009)). No evidence of skin sensitization was found in volunteers (HSDB (2009)). However, details on tests methods and the results were not provided.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro test, negative results in the Ames test were reported (PATTY, 5th (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects, Respiratory tract irritation) Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description of lethargy as the toxic sign observed in acute oral studies in rats and mice (PATTY, 5th (2001)), the substance was classified as Category 3 (narcotic effects). Furthermore, it was reported as effects in humans that there were effects on mucous membranes of the nasal cavity and upper respiratory tract, consequently burning sensation, bronchoconstriction, choking and coughing were noted (PATTY, 5th (2001)). Therefore, the substance was classified as Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 17-day gavage study in rats (dose levels: 100 - 1000 mg/kg/day, converted dose levels as those of 90-day study: 18.8 - 188 mg/kg/day), food consumption, body weight gain, hematology, clinical chemistry, gross and histopathological findings were normal (PATTY, 5th (2001)). In addition, in the 13-week oral toxicity study in rats administered at 50 - 500 mg/kg, no unfavorable effects were observed except a decrease in relative pituitary weight of females in the high dose (HSDB (2009)). Thus, in spite of the classification applicable to "Not classified" in the oral route, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible" due to no information available for the other routes (inhalation and dermal exposure).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information