GHS Classification Result

Chemical Name:Disodium silicate pentahydrate
CAS:10213-79-3

Result:
ID: 22A4028
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".
11 Self-heating substances and mixtures Not classified - - - - Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (Na), its water solubility is 610 mg/L (30 degC) (SIDS (Access on May. 2010)) and it is considered stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - The substance is an inorganic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen. Since no test results using designated methods for classification of oxidizing solids are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the mouse LD50 value of 1200 - 1700 mg/kg (SIDS (Access on May 2010)), the substance was classified as Category 4. [Refer to sodium metasilicate (CAS: 6834-92-0) as the anhydrous form of this substance.]
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 1 based on the documented case of "corrosive" resulted from the rabbit test (OECD TG 404) in which dose of 0.5 g of test substance for 4 hours caused necrosis at application site, and symptoms did not disappear after 14 days, primary skin irritation index value was 7.8 - 8.0 (SIDS (Access on May 2010)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
The substance was classified into Category 1 because its preexisting classification for skin corrosion/irritation is Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data were available. As relevant information, negative result was reported in the mouse local lymph node assay (OECD TG429) of anhydrous compounds. In humans, urticaria by contact to skin was observed in one case and ulcer formation and wheal were observed in patch tests for the same person (but not in 30 control subjects) (SIDS (Access on Dec. 2008)). However, details were not provided.
5 Germ cell mutagenicity Not classified - - - - No data are available in this substance. The substance was classified as "Not classified" based on the negative results in the chromosome aberration test using bone marrow of mice after oral administration with an anhydrous form of this substance (in vivo mutagenicity test in somatic cells) (SIDS (Access on Dec. 2008)). As relevant information, as for in vitro study, the negative results in the Ames test were reported (SIDS (Access on Dec. 2008)).
6 Carcinogenicity Classification not possible - - - - No data available. As relevant information, no carcinogenicity were found in the oral administration tests for 14 months and 2 years to rats with anhydrous compound (SIDS (Access on Dec. 2008), IUCLID (2000)). However, there are no data using other animal species.
7 Reproductive toxicity Classification not possible - - - - No data were available. In the oral administration study using the anhydrous compound with pregnant mice during the organogenetic period, no developmental effects were observed (SIDS (Access on Dec. 2008)). However, there were no data on the effects on reproductive function, fertility of parent animals.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
No data were available for the substance itself, however, in the oral toxicity studies in rats using anhydrous compound (dose levels: 538 - 2000 mg/kg (males), 910 - 2600 mg/kg (females)), lethargy, increased breathing frequency, mydriasis and convulsion were observed (SIDS (Access on Dec. 2008)). In the oral toxicity study in mice (dose levels: 500 - 1920.8 mg/kg (males), 500 - 1372 mg/kg (females)), lethargy was also observed (SIDS (Access on Dec. 2008)). By converting the doses as equivalent doses to pentahydrate, those values that neurotoxic signs occurred were equivalent to those within Category 2 of the guidance values, therefore, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In rats exposed to 500 pm of silicate (equivalent to 1259 mg/kg/day as sodium metasilicate, pentahydrate) for 8 weeks by feeding, it was reported that no other effects were seen except for reductions of concentrations in calcium and magnesium and decreased zinc concentration in liver (SIDS (Access on May 2010)). However, due to no description of histopathological findings and limited endpoints in addition to limitation of the study design (single dose with males only), "Classification not possible" was judged as relevant from the study. Otherwise, in the 3-month study of anhydrate in rats via drinking water (similar to OECD TG 408), the NOAEL was determined as 227 - 237 mg/kg/day based on no effects seen up to the highest dose (SIDS (Access on Dec. 2008)). It was also reported that in the 3-month study of anhydrate with mice via drinking water, no remarkable findings except for an increase in liver weight as well as a decrease in leukocyte count in females at the highest dose (ca. 600 mg/kg/day), and that the NOAEL was determined as 260 - 284 mg/kg/day (SIDS (Access on Dec. 2008)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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