GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Calcium nitrite
CAS：13780-06-8
Result：
| ID: | 22A4023 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it contains a metal (Ca), its water solubility is 94.6 g/100 g water (25 degC) (Lide (90th, 2009)) and it is considered that the substance doesn't react strongly with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (Crystals) at room temperature (Merck (14th, 2006)). |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Although this substance is an inorganic compounds containing oxygen, classification is not possible because there is no data available. As relevant note, the substance is classified into Division 5.1 (NITRITES, INORGANIC, N.O.S.), PGII (UN2627) in UNRTDG (UN2627). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (crystals) at room temperature (Merck, 14th (2006)) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | In the UDS test (in vivo genotoxicity test in germ cell) using germ cells obtained from mice after administration of nitrite, no UDS reaction was noted (JECFA NITRITE (WHO Food Additives Series 35) (1996)). However, it was uncertain whether the test was performed using calcium nitrite as the test substance. Therefore, the substance was classified as "Classification not possible". |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of data. As relevant information, the IARC (IARC Vol. 94 (2010)) describes as follows: there is limited evidence in humans for the carcinogenicity of nitrite in food. Nitrite in food is associated with an increased incidence of gastric cancer. There is limited evidence in experimental animals for the carcinogenicity of nitrite per se. Based on the assessment described above, it was concluded that the criterion of carcinogenicity was "Group 2A" under the condition that orally ingested nitrate or nitrite was nitrosated in vivo. In the comprehensive evaluation of the IARC (IARC Vol. 94 (2010)), there are supplementary comments: there is in vivo interconvertible cycles in humans that involve nitrate and nitrite. Nitrosating agents that arise from nitrite under acidic gastric conditions react readily with nitrosatable compounds, especially secondary amines and amides, to generate N-nitroso compounds. These nitrosating conditions are enhanced following ingestion of additional nitrate, nitrite or nitrosatable compounds. Some of the N-nitroso compounds could generate known carcinogens under these conditions. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data were available for this substance itself. Furthermore, it was reported that in the animal experiments for sodium and potassium nitrites as soluble nitrite salts, comparable positive and negative results were reported (ECETOC TR27 (1988), NTP TR495 (2001)). Therefore, the substance was classified as "Classification not possible". |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood, cardiovascular system) |
|
Danger | H370: Causes damage to organs (blood, cardiovascular system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
No data were available for this substance itself. However, it was reported that nitrites causes methemoglobinemia in humans, and that nitrites produce muscular relaxation, especially in the veins, myocardial and peripheral arteries, and subsequently hypoxia by hypotension (PIM G016 (1996)). Thus, the substance was classified as Category 1 (blood, cardiovascular system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood), Category 2 (respiratory system, liver, kidney, adrenal gland, cardiovascular system) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (blood) H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver, kidney, adrenal gland, cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
No data were available for this substance itself. However, it was reported that in the animal experiments for sodium and potassium nitrites as soluble nitrite salts, increases in methemoglobin concentration was observed in doses within Category 1 (FAO/WHO JECFA Food Additive Series 50 (2003)), and the microscopic changes observed in the dose levels within Category 2 were as follows: hypertrophy of the glomerular zone in the adrenal cortex, congestion of liver and spleen, inflammatory and degenerative changes in the kidneys, emphysema in respiratory organs and degenerative foci in the heart (ECETOC TR No. 27 (1988)). As described above, the substance was classified as Category 1 (blood), Category 2 (respiratory system, liver, kidney, adrenal gland, cardiovascular systems). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |