GHS Classification Result

Chemical Name:Sodium metavanadate
CAS:13718-26-8

Result:
ID: 22A4022
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ATSDR DRAFT (2009))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (ATSDR DRAFT (2009))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ATSDR DRAFT (2009))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (V), its water solubility is 21 g/100 g (25 degC) (Lide (88th, 2008)) and it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - This substance is an inorganic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen. However, due to lack of additional data, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 values of 98 mg/kg (CICADs 29 (2001)) and 212 mg/kg (DFGMAK-Doc.25 (2009)), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The rat LC50 values of 4.98 mg/L (male) and 3.73 mg/L (female) was documented (DFGMAK-Doc.25 (2009)). Because of the uncertainty of the exposure time, the classification was not possible. Based on the state of solid (GHS definition), it was presumed that the tests were carried out with dust, and the criterion values for dust/mist were adapted.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In the rabbit test, 20% solution of test substance caused irritation (EHC 81 (1998)). In the human case, 10% solution caused primary skin irritation (NIOSH Publications 77 - 222 (1977)). Based on these documents, the substance was classified as Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Insufficient data were available. In the case report of workers exposed to vanadium compound, patch tests to nine workers who presented dry dermatitis revealed one positive result, thus it was suggested that dry dermatitis was allergic reaction (DFGMAK-Doc. Vol. 25 (2009), original literature: SJOEBERG, S.-G. Vanadium pent oxide dust (1950)). Five of 125 workers with contact dermatitis by cement revealed a positive reaction to the substance in patch tests (EHC 81 (1988), original literature: Schweizerische Medizinische Wochenschrift NI'. 32 (1968)). However, neither report has clear mention that this substance is a skin sensitizer. Furthermore, none of the 17 workers that were exposed to dust containing vanadium, while cleaning boilers in oil power plant revealed positive reactions in patch tests (DFGMAK-Doc. Vol. 25 (2009), original literature: British Journal of Industrial Medicine (1980)).
5 Germ cell mutagenicity Classification not possible - - - - Although there was a positive result in the dominant lethal test (in vivo inheritable mutagenicity test in germ cell) in mice administered test substance by drinking water, the test did not meet standard protocol, and insufficient methods were used in the test such as no positive controls were employed and the examinations of female mice were conducted on the 10th day after mating. Therefore, it was concluded that there was a considerable limitation for utilization of this negative data (DFGMAK-Doc. Vol. 25 (2009)). No other in vivo test data are found. Accordingly, it was classified as "Classification not possible". As relevant information, as for in vitro tests, there are negative results in the Ames test (NTP DB (Access on May 2010)), positive results in the chromosomal aberration test and the micronucleus test using human lymphocytes (CICADs 29 (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the feeding study in female rats during pregnancy and lactation periods (through day 21 postpartum), decreased survival of pups (PATTY, 5th (2001), ATSDR DRAFT (2009)), decreased maternal body weight gain and decreased food consumption as maternal toxicity were observed (ATSDR DRAFT (2009)). In the oral study in rats administered from 60 days before mating for males and during mating and pregnancy/organogenetic periods for females, there was no influence in fertility and reproductive functions of parents, and there wasn't maternal toxicity either, but, significantly lower body weight and body length were observed in both sex of pups until 21th day after birth (Japan Society For Occupational Health (JSOH), Recommendations for allowable concentrations, (2003), CICADs 29 (2001)). In an oral administration study via drinking water to male mice from 64 days before mating, a decrease in spermatid/spermatozoa count and in conception rate were observed in the high dose group (ACGIH (2009), CICADs 29 (2001)). There was some conclusion that there was no evidence of the direct reproduction/developmental toxicity of this substance, considering its maternal toxicity (CICADs 29 (2001)). However, the toxic effects cannot be denied. Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system) Danger H370: Causes damage to organs (respiratory system, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
None of the data limited to this substance were available. In humans, however, as remarkable symptoms in the acute occupational exposure to the dust of the mixture consisting of this substance, vanadium pentaoxide, and ammonium metavanadate etc., severe neurosis and disorders of nervous system containing tremor of fingers and hands were reported (PATTY, 5th (2001)). It was also reported about the effects of acute occupational exposure to vanadium as follows: rhinitis with a sneezing or coughing and burning sensation in the throat as mild symptoms, and irritation of the upper respiratory tract and bronchitis with expiratory dyspnea and bronchospasm as moderate symptoms, and bronchitis and bronchopneumonia as severe symptoms (PATTY, 5th (2001)). Furthermore, in the animal experiments, toxic signs reflecting the effect on nerve system such as reduced motility, torpor, paralysis of hind legs and decreased sensitivity to pain, etc. were reported as common symptoms in rats exposed to vanadium compounds (DFGMAK-Doc. 25 (2009)). Based on the information, the substance was classified as Category 1 (nervous system, respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
No human information limited to the substance was available. It was reported, however, that workers who were occupationally exposed to dust mixtures of the substance and vanadium pentaoxide for several months or years caused various signs such as conjunctivitis, rhinitis, irritation of the mucous membrane of the respiratory tract, coughing with hemorrhage, dyspnea, convulsive bronchitis and chronic bronchitis, etc. (DFGMAK-Doc. 4 (1992)), and was reported, in numerous reports, that workers exposed to vanadium dusts occupationally revealed the symptoms as follows: bronchitis, bronchospasm, persistent cough, irritating symptoms of nasal mucosa, wheezing, rales, coarse crackles, greenish tongue, and dyspnea or palpitation were added at higher concentrations. In addition, the risk of occurrence of pulmonary emphysema was pointed out (Japan Society for Occupational Health (JSOH), Recommendations for allowable concentrations, vol. 45 (2003)). Thus, the substance was classified as Category 1 (respiratory system). Besides, regarding the toxicity studies in experimental animals, hypertrophy and hyperplasia of white pulp in spleen were observed in rats exposed to this substance via drinking water for three months, while decreases in hemoglobin concentration and hematocrit value and increases in reticulocyte were observed in another 10-week drinking study with rats. Both were inconsistent findings, but it was described the cause of contradicting results were unknown (ATSDR (2012)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 2 from its 48h-LC50 = 2.3 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2 since its acute toxicity is Category 2 and adequate data on rapid degradation are not available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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