GHS Classification Result

Chemical Name:Tungsten(VI) oxide
CAS:1314-35-8

Result:
ID: 22A4006
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible solid. (GESTIS (Access on Apr. 2010))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible solid. (GESTIS (Access on Apr. 2010))
11 Self-heating substances and mixtures Not classified - - - - Non-combustible solid. (GESTIS (Access on Apr. 2010))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (W), its water solubility is 1.3 g/100 ml (HSDB (2009)) and it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - This substance is inorganic compound containing oxygen. Since no test results are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 840 mg/kg bw (ATSDR (2005)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Because no in vivo test data available, the classification was not possible. In addition, as for in in vitro studies, negative results in the Ames test were reported (NTB DB (Access on May. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although it was reported that in the case of intratracheal instillation to rats, proliferation of leukocytes and histiocytes with subsequent slight fibrosis were seen in the lungs, especially at the injection site (DFGMAK-Doc. 23 (2007)), no other data were available. Thus, "Classification not possible" was concluded due to lack of sufficient data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 70 days feeding study with rats, deaths were observed in the groups given at dietary concentration of 0.5% (converted dose level as that of 90-day study: approx. 194 mg/kg) and more, but only body weight loss was described at lower concentration of 0.1% (DFGMAK-Doc. 23 (2007)). In humans, it was reported that in the survey of workers with long industrial experience, no pneumoconiosis developed among those exposed to solely tungsten or its insoluble compounds (ACGIH (2001)). On the other hand, there was the report mentioning that symptom of pulmonary fibrosis was observed in the workers exposed to dust containing this substance (ATSDR (2005)). But, the report also described that the original data lacked critical information regarding the smoking history and past medical histories of workers examined. As described above, in spite of multiple hazard information, these were insufficient to use properly as evidence to classify. Therefore, the classification was concluded as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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