GHS Classification Result （Revision of the past classification result）

Chemical Name：Dipotassium nickel (II) tetracyanide
CAS：14220-17-8

Result：
ID: 21C0018
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solids Classification not possible - - - - The substance is an inorganic cyanide and is considered to be "Not combustible". However, no data are available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Classification not possible - - - - The substance is an inorganic cyanide and is considered to be "Not combustible" (non-pyrophoric). However, no data are available.
11 Self-heating substances and mixtures Classification not possible - - - - The substance is an inorganic cyanide and is considered to be "Not combustible" (non-self heating). However, no data are available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Classified into Not classified from the description of "Very soluble in H2O" Sax (11th, 2004).
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 275 mg/kg (RTECS (2004); Journal of Pharmaceutical Sciences) for mice, the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (room temperature)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Since nickel and its compounds are classified into Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and respiratory tract sensitizer in DFG (MAK/BAT No.43 (2007)), the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Soluble nickel is classified as a skin sensitizer by ACGIH (ACGIH-TLV (2008)). In addition, nickel and its compounds are classified into Category 1 for skin sensitizer in Japan Society For Occupational Health (JSOH), (Recommendations for allowable concentrations (2008)) and skin sensitizer in DFG (MAK/BAT No. 43 (2007)). Based on these data, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests or strong positive results from in vitro mutagenicity tests with multiple indexes. From in vitro mutagenicity tests, there is a report of a positive chromosomal aberration test using mouse Fm3A breast cancer cells (IARC vol. 49 (1990)).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance is classified into "Group 1" (IARC 49 (1990)), "K" (corresponds to Category 1A as nickel compounds) (NTP RoC (11th, 2005)), Category 2B (corresponds to Category 2 as nickel) in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2004)) and "A4" (corresponds to "Not classified" as soluble inorganic nickel) (IRIS (1991), ACGIH-TLV (2004)). According to IARC and NTP, the substance was classified into Category 1A.
7 Reproductive toxicity Classification not possible - - - - No data available. Refer also to other nickel compounds (nickel chloride, nickel sulfate).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		No data for the substance is available. However, since soluble inorganic nickel compounds are irritating to the respiratory tract in ACGIH-TLV (2004) (ACGIH (7th, 2001)), the substance was classified into Category 3 (respiratory tract irritation). For health hazards, refer also to other nickel compounds (Nickel chloride, Nickel sulfate).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		No data for the substance is available. However, since soluble inorganic nickel compounds can induce effects on the central nervous system (ACGIH TLV-Basis-Critical Effects: Central Nervous System; ACGIH-TLV (2004)), the substance was classified into Category 1 (central nervous system). For health hazards, refer also to other nickel compounds (Nickel chloride, Nickel sulfate).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 39000 microg/L for fish (guppy) (AQUIRE, 2003)
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and the behavior in water and bioaccumulative potential are unknown from which it is a metal compound.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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