GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Nickel (II) nitrate
CAS：13138-45-9
Result：
| ID: | 21C0015 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance is nitrates and contains chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | The substance is classified into Division 5.1 (Oxidizing substances), PG III (solids) in UNRTDG. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | The substance is considered to be stable against water (Weiss (2nd, 1986)) since data are available that water solubility is 99.2 g/100 g water (25 degC) (Lide (84th, 2003)) though it is a metal compound. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Category 3 |
|
Warning | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 3 since the substance is classified into Division 5.1, PG III (solids) in UNRTDG. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Category 1 |
|
Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Since nickel and its compounds are classified into R42/43 in EU classification (EU-Annex I (access on Jan. 2009)) and Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)), the substance was classified into Category 1. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Since nickel and its compounds are classified into R42/43 in EU classification and Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)), the substance was classified into Category 1. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative results in dominant lethal test (in vivo heritable germ cell mutagenicity test) and micronucleus test (in vivo somatic cell mutagenicity test) by intraperitoneal administration to mice (EHC 108 (1991)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (EHC 108 (1991)). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the classifications of "Group 1" in IARC (IARC 49 (1990)), "Carcinogenicity. Category 1" in EU classification (EU-Annex I (2009)) and "1" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)), the substance was classified into Category 1A. Soluble inorganic nickel is classified into "A4" in ACGIH (ACGIH (2001)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. Refer also to other nickel compounds (nickel chloride, nickel sulfate). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. For health hazards, refer also to other nickel compounds (nickel chloride, nickel sulfate). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. For health hazards, refer also to other nickel compounds (nickel chloride, nickel sulfate). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 48h-LC50 = 0.461 mg/L (1.435 mg/L as nickel (II) nitrate) for Crustacea (Moina macrocopa) (Hazard Assessment Report (CERI, NITE) (Preliminary version), 2006). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2, and the behavior in water and bioaccumulative potential are unknown from which it is a metal compound. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |