GHS Classification Result （Revision of the past classification result）

Chemical Name：Dimethyl carbonate
CAS：616-38-6

Result：
ID: 21C0004
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - −
2 Flammable gases （including chemically unstable gases） - - - - - −
3 Aerosols - - - - - −
4 Oxidizing gases - - - - - −
5 Gases under pressure - - - - - −
6 Flammable liquids - - - - - −
7 Flammable solids - - - - - −
8 Self-reactive substances and mixtures - - - - - −
9 Pyrophoric liquids - - - - - −
10 Pyrophoric solids - - - - - −
11 Self-heating substances and mixtures - - - - - −
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - −
13 Oxidizing liquids - - - - - −
14 Oxidizing solids - - - - - −
15 Organic peroxides - - - - - −
16 Corrosive to metals - - - - - −

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - −
1 Acute toxicity （Dermal） - - - - - −
1 Acute toxicity （Inhalation: Gases） - - - - - −
1 Acute toxicity （Inhalation: Vapours） - - - - - −
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - −
2 Skin corrosion/irritation - - - - - −
3 Serious eye damage/eye irritation - - - - - −
4 Respiratory sensitization - - - - - −
4 Skin sensitization - - - - - −
5 Germ cell mutagenicity - - - - - −
6 Carcinogenicity - - - - - −
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a developmental toxicity test in mice exposed by inhalation to 300 - 3000 ppm during the organogenesis period, maternal body weight gain and food consumption were reduced at 3000 ppm, and postimplantation loss due to increased resorptions, and increased number of stunted fetuses were observed (HSDB (2003)). At the 3000 ppm dose, total incidences of fetal malformations were significantly increased and included cleft palate, microtia, and multiple skull bone malformations (HSDB (2003)). Since the effects on reproduction and fetal development, especially the increased incidences of fetal malformations, were observed at a dose level in which general toxicity such as decreased body weight gain in the parental animals was manifested, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is a report that the substance has an oral LD50 value in rats and mice between 6.4 and 12.8 g/kg. Since exposure symptoms included weakness, ataxia with gasping, and unconsciousness (PATTY (5th, 2001)), effects on the nervous system were suspected. The effects were observed at dose levels which exceeded the guidance value range. Exposure to the substance by inhalation of a concentration of 8000 ppm for 2-hour (4-hour equivalence: 20.8 mg/L) caused gasping, loss of coordination, and pulmonary edema with death occurring in a period of 2-hour (PATTY (5th, 2001)). Classification was not possible since the reported effects appeared at dose levels exceeding the guidance value range.
9 Specific target organ toxicity - Repeated exposure - - - - - −
10 Aspiration hazard - - - - - −

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - −
11 Hazardous to the aquatic environment （Long-term） - - - - - −


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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