Chemical Name:Cyclohexene
CAS:110-83-8
ID: | 21B3133 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2009 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 | Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 2 (GHS criteria: flash point <23 degC, initial boiling point >35 degC) from flash point -6 degC (closed-cup) (ICSC (1999)) and initial boiling point 83 degC (ICSC (1999)). | |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Auto-ignition point is 244 - 310 degC (ICSC (1999), NFPA (13th, 2006), Hommel (1996)) exceeding 70 degC. |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on a LD50 value of 1000 - 2000 mg/kg for rats (mortality of 3/5 at 2000 mg/kg in both sexes)(OECD TG401, "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council)(access on Jun 2009)), the substance was classified into Category 4. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on a LD50 value of >16,220 mg/kg for guinea pigs (SIDS (2002)), the substance was classified as "Not classified". |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | Although a LCLo value is >6370 ppm for rats (SIDS (2002)), classification was not possible since determination of the category (Category 4 or "Not classified") is impossible. Since the LCLo value is lower than 90% of saturated vapour pressure concentration of the substance (117,105 ppmV: calculated from the vapour pressure of 89 mmHg at 25 degC (Howard (1997))), it is considered that the test was conducted for gas. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on reports of erythema in humans (HSDB (2009)) and "direct contact with the skin causes irritating effects and delipidation of the skin" (PATTY (5th, 2001)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). |
3 | Serious eye damage/eye irritation | Category 2 | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on a report of "eyes-redness" for humans (HSDB (2009)), the substance was classified into Category 2. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | According to the guidance, classification was not possible due to lack of data from in vivo mutagenicity tests or strong positive results from in vitro mutagenicity tests with multiple indexes. There are reports of negative bacterial reverse mutation test (OECD TG471) and CHL/IU cell chromosomal aberration test (OECD TG473) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), access on June 2009). |
6 | Carcinogenicity | Not classified | - | - | - | - | In a 104 week inhalation test in rats, the incidence of hepatocellular adenoma and carcinoma (combined) was increased in the males. However, the increase was slight, and increased incidences of tumors in other tissues/organs or females were not noted (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2003)). In a 104-week inhalation test in mice, increased incidences of tumors were not observed in either sex (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2003)). Since there were no evidences of carcinogenicity in the cited tests, the substance was classified as "Not classified". |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a combined repeat dose and reproductive/developmental toxicity test in rats by oral administration (OECD TG422), there were no effects on the reproductive performance of the parental animals or development and growth of the offspring ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on June 2009)). However, classification was not possible due to lack of sufficient data including teratogenicity. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects, Respiratory tract irritation) | Warning | H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
For humans, there are reports of "transient CNS depression" (PATTY (5th, 2001)), "may cause effects on the central nervous system" and "cough and drowsiness" (HSDB (2009)). In oral tests in rats and mice and inhalation test in rats, decrease in locomotor activity, sleepiness and ataxia were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on June 2009), SIDS (2002)) and narcotic effects were indicated (PATTY (5th, 2001)). Based on the available information, the substance was classified into Category 3 (narcotic effects). Additionally, since there is a report of respiratory tract irritation in humans (HSDB (2009)), the substance was classified into Category 3 (respiratory tract irritation). | |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Significant toxic effects were not observed at dose levels beyond the guidance value range for Category 2 in a combined repeat dose and reproductive/developmental screening test in rats (OECD TG422, highest dose: 265 mg/kg (equivalent)) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on June 2009)) or in 6-month inhalation exposure tests in rats, rabbits and guinea pigs (highest dose: 2.02 mg/L (equivalent)) (SIDS (2002)). According to the data, the substance corresponds to "Not classified" with the oral and inhalation routes. Classification was not possible due to lack of data with dermal exposure route. |
10 | Aspiration hazard | Category 1 | Danger | H304: May be fatal if swallowed and enters airways |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ... |
There are reports that "when ingested, it represents a low to moderate pulmonary aspiration hazard" (PATTY (5th, 2001)) and "swallowing the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis" (HSDB (2009)).The substance is liquid and the kinematic viscosity is 0.77 mm2/s (calculated value) at ambient temperature. The substance was classified into Category 1. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 48h-EC50 = 2.1 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000, etc). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2003)). | |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |