GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Cadmium sulfate
CAS：10124-36-4
Result：
| ID: | 21B3101 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | The substance is considered to be stable against water since data are available that water solubility is 75.5 g/100 mL (0 degC) (ICSC (2007)) through it contains metals (Cd). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance is inorganic compound containing oxygen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on a LD50 value of 357 mg/kg for rats (CaPSAR (1994)), the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on a number of case reports of skin irritation following exposure to high levels of cadmium sulfate (CaPSAR (1994)), the substance was classified into Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There are a number of case reports of eye irritation following exposure to high levels of cadmium sulfate (CaPSAR (1994)). The substance was classified into Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although no data from in vivo mutagenicity tests are available for the substance, there are strong positive results from in vitro mutagenicity tests with two indexes (gene mutation, chromosomal aberration). The substance is a water soluble cadmium compound. It cannot be excluded that the substance can exert genotoxic effects in consideration of germ cell mutagenicity potential suggested with cadmium chloride, a representative water soluble cadmium compound. Based on the information, the substance was classified into Category 2. Refer also to cadmium chloride (CAS: 10108-64-2). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and into Category 1 in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
In an inhalation developmental toxicity test in rats, lower body weight of the offspring and increased mortality during the first 10 days were observed (EHC 134 (1992)). However, since there was no information for the maternal general toxicity the substance was classified into Category 2. As relevant information, the substance is classified into R60/61 in EU classification. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, digestive system) |
|
Danger | H370: Causes damage to organs (respiratory system, digestive system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
No data for the substance is available. However, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, alimentary system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, kidney, bone) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, bone) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In an inhalation test with rats, a decrease in blood calcium concentration was noted and X-ray analysis of the bones indicated osteomalacia following exposure to the substance at 2.8 microg/L, 4h/day, for 4 months. In inhalation tests with hamsters, an increased incidence of alveolar hyperplasia and interstitial fibrosis was found following exposure at 0.3 microg/L, 8h/day, for 13 - 65 weeks (EHC 134 (1992), IARC 58 (1993)) and multifocal bronchoalveolar hyperplasia were observed following exposure at 0.01 microg/L, 19h/day, for 50 - 70 weeks (EHC 134 (1992)). Based on the data, target organs were considered to be bone and respiratory system. The effects on animals were observed at dose levels within the guidance value range for Category 1. In addition, as chronic effects of cadmium compounds to humans, "renal dysfunction such as glomerular proteinuria, hypercalciuria, disturbances in rate of calcium to phosphate, hypophosphataemia, formation of renal stones, osteomalacia and osteoporosis" are characteristic (EHC 134 (1992)). Based on the information, the substance was classified into Category 1 (respiratory system, kidney, bone). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 96h-LC50 = 0.001 mg/L (0.002 mg/L as cadmium sulfate) for fish (King salmon) (EHC 135, 1992) |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |