GHS Classification Result （Revision of the past classification result）

Chemical Name：o-sec-Butylphenol
CAS：89-72-5

Result：
ID: 21B3097
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Classified into Not classified since flash point is >93 degC under closed-cup test method from which data are available that flash point is 107 degC (HSDB (2005)), 112 degC (Hommel (1996)) though the test method for both data is unknown.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) in the molecule which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available. Information is available that the substance is not suitable for containers since it is corrosive to steel (Hommel (1996)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 2.7 g/kg (ACGIH (2001)) and 500 - 1000 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)) for rats, the category with higher hazard was adopted and the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of 5560 mg/kg for rabbits (RTECS (2008), the original literature: NTIS Clearinghouse for Scientific & Technical Information OTS 0572448), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Although A LC50 value of >290 ppm (>1.78 mg/L) for rats (RTECS (2008), the original article: NTIS Clearinghouse for Scientific & Technical Information OTS 0572448) corresponds to Category 4 or "Not classified", classification was not possible due to lack of sufficient data. Since the test concentration was higher than saturated vapour pressure concentration (65.7 ppm), the classification criteria for mist were adopted.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Severe burns resulted from the application of the substance to rabbit skin for 24-hour (ACGIH (2001)). Acute occupational exposures have resulted in skin burns (ACGIH (2001)). Based on the reports, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since severe eye injury occurred in a rabbit test (ACGIH (2001)) and the substance is classified into Category 1 for skin corrosion, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of negative Ames tests (NTP DB (access on May. 2009), "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)), and a positive Chinese hamster lung cell chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a combined repeat dose and reproductive/developmental toxicity screening test in rats by oral administration (OECD TG422 (GLP)), there were no effects on the mating index and fertility index of male and female animals, the pregnancy maintenance, delivery and lactation of the females, and the viability, sex ratio, development and morphology of the offspring at doses that were parental general toxic ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)). However, classification was not possible due to lack of sufficient data for fetal developmental toxicity including teratogenicity.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In an oral dose test in rats, decrease in locomotor activity and crouching were observed in most of the animals in the 250 - 2000 mg/kg groups, and decreased respiration, abnormal respiratory sounds and respiratory distress were found in some of the animals. In a pathological examination of dead animals, red and dark-red areas were noted in the lung ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)). These findings were observed at dose levels within the guidance value range for Category 2, and the respiratory tract was estimated to be a target organ ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)). The substance was classified into Category 2 (respiratory tract). Changes in gastrointestinal tract (cloudy thickening in the mucosa of forestomach, etc.) are considered to be a local effect, since the substance is corrosive to the skin.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a combined repeat dose and reproductive/developmental screening test in rats by oral administration, decrease in locomotor activity in the males during the early phase of the treatment period was the only finding in 60 mg/kg/day (90-day equivalent: approximately 28 mg/kg/day) group. In the 300 mg/kg/day (90-day equivalent: approximately 149 mg/kg/day) group, increase in total cholesterol level and centrilobular hepatocellular hypertrophy were observed in males, and an increase in relative liver weight was observed in both sexes ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on May 2009)). However, since effects at dose levels around the upper limit of the guidance value range (100 mg/kg/day) for Category 2 are not clear, classification was not possible due to lack of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 4.0 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2001)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information