NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：Allyl chloride
CAS：107-05-1

Result：


ID:	21B3088
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 2 since flash point is -32 degC (closed-cup) and boiling point is 45 degC (ICSC (2004)). The substance is classified into Class 3, Subsidiary risk 6.1, PG I in UNRTDG (UN1100).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification is not possible since no data are available though the substance contains unsaturated bond in the chemical structure. The substance is classified into Class 3, Subsidiary risk 6.1, PG I in UNRTDG (UN1100).
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 390 degC (ICSC (2004)), 392 degC (HSDB (2006)) and 485 degC (NFPA (13th, 2006)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to liquid (low boiling point) substances are not available. Information is available that the substance does not corrode mild steel or cast iron if the temperature is not high, but corrodes aluminum (Solvents Handbook, Ohmsha Ltd. (1994)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on LD50 values of 450, 460 and 700 mg/kg for rats (SIDS (2003)), the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on LD50 values of 2200 mg/kg for rats (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)) and 2026 mg/kg for rabbits (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	LC50 (4h) values are 2100 ppm, >=2000 ppm (SIDS (2003)), 1138 ppm and 2620 ppm (DFGOT vol. 18 (2002)) for rats. The substance was classified into Category 3 since most of the values are in this category. Since the saturated vapour pressure concentration of the substance at 25 degC was 484,211 ppmV, and all of the LC50 values were lower than 90% of saturated vapour pressure concentration of the substance, the classification criteria for gas was adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	There are reports of "mild irritation" and "local skin injury (erythema, swelling, skin necrosis)" in skin irritation tests using rabbits and mice (SIDS (2003), Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). In addition, "erythema, burning sensation and pain of skin, and severe bone pain within few hour" are reported following contact with human skin (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). Although the degree of irritation is not clear, irritating effects are clearly reported, therefore the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	There is a result of "slightly irritating" in a rabbit eye irritation test (SIDS (2003), Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). On the other hand, there is a report that eye contact may cause pain and severe irritation with corneal injury that may result in permanent impairment of vision, even blindness (ACGIH (7th, 2001)). It is possible that the substance causes irreversible irritation in the eyes. This substance is classified as a skin corrosive substance. Based on these information, the substance was classified into Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results in 2 in vivo mutagenicity tests (dominant lethal test, bone marrow chromosomal aberration test) (SIDS (2003)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a positive Ames test (SIDS (2003)) and a positive CHL cell chromosomal aberration test (IARC vol. 71 (1999)).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The substance is classified into "A3" by ACGHI (1996) (ACGIH-TLV (2009)) and into Category 3 in EU classification (EU-Annex I (access on May 2009)). In addition, the substance is classified into "Group 3" in IARC (IARC vol. 71 (1999)). 104-week inhalation tests were conducted in rats and mice. In F344/DuCrj (Fischer) rats, increased incidences of transitional cell carcinoma in the urinary bladder were observed in the males, and the result was considered to be clear evidence of carcinogenic activity. Incidence of follicular adenoma in the thyroid was also increased in the males. Increased incidence of tumor was not noted in the females. In Crj:BDF1 mice, incidence of Harderian gland adenoma was increased in both sexes, and the result was considered to be clear evidence of carcinogenic activity (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2003)). The Ministry of Health, Labour and Welfare has made a public announcement on guidelines in order to prevent the impairment of worker's health based on Industrial Safety and Health Act Article 28-3 (2009). Based on all information, the substance was classified into Category 2.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In an inhalation developmental toxicity test in rats, significant increases in resorption sites, post-implantation loss and pre-implantation loss were observed at dose levels in which maternal general toxicity was observed (SIDS (2003)). Based on the data, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, nervous system, kidney, liver, heart), Category 3 (narcotic effects)		Danger Warning	H370: Causes damage to organs (respiratory system, nervous system, kidney, liver, heart) H336: May cause drowsiness or dizziness (narcotic effects)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	"Respiratory tract irritation" and "unconsciousness" are reported in humans exposed to the substance (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). In animals, histological changes in the kidney (cloudy swelling of convoluted tubules, degeneration, focal necrosis of podocyte) and liver (dilatation of sinusoid and cloudy swelling of hepatocyte), degeneration of cardiomyocyte and symptoms of nervous system (decreased activity, lethargy, paralysis of hind limbs, tremor and convulsion) are reported at 100 mg/kg following oral exposure in rats (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). In inhalation tests with rats and mice, pulmonary oedema and congestion of the liver and kidneys were observed at dose levels of 3.506 mg/L, 8.2 mg/L (rat), and 3.13 mg/L (mouse) (DFGOT vol. 18 (2002)). In inhalation tests with rats and guinea pigs, marked injury to the lungs and kidneys were reported (PATTY (5th, 2001)). Based on these data, the respiratory system, nervous system, kidney and liver were regarded as target organs. The substance appeared to also have a narcotic effect. Additionally, the effects in animals were observed at dose levels within the guidance value range for Category 1. The substance was classified into Category 1 (respiratory system, nervous system, kidney, liver, heart) and Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, kidney, heart, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, kidney, heart, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In humans, "debilitation, paresthesia and extremity paralysis" (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 2 (2003)), "hepatic dysfunction, renal dysfunction and peripheral neuropathy were reported following chronic exposure" (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). Additionally, "renal toxicity (changes in glomerular membrane permeability, renal tubular degeneration, origuria, pain during urination, nocturia), neuropathy (shivering of hands and eyelids, increased tendon and periosteal reflexes, hyperhidrosis, hypothermia, cyanosis, sleep disorder, paresthesia of limbs), effects on cardiovascular system (decrease in myocardial contraction, diminished heart sounds, cardiac murmur, pain) and abnormal hepatic function were reported following chronic exposure" (BUA 186 (1995)). In a rat inhalation test: a decrease in conduction velocity of motor neuron and sensory neuron in the tail and debilitation of hind limbs associated with decrease in action potential amplitude was reported following exposure at 0.181 mg/L (an equivalent); CNS depression was reported at 0.1 mg/L (an equivalent); and necrosis of hepatocytes around central vein (slight in degree) was reported at 0.0097 mg/L (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). Based on the reports, target organs were considered to be nervous system, kidney, heart and liver. Effects on animals were observed at dose levels within the guidance value range for Category 1. Based on the data, the substance was classified into Category 1 (nervous system, kidney, heart, liver).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3 from its 96h-TLm = 19780 microg/L for fish (Fathead minnow) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), Vol. 3, 2004).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Classified into Not classified since it is rapidly degradable (BOD degradation rate: 62% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1986)) and the bioaccumulative potential is low (BCF = 5.6 (Toxicity Testing for Existing Chemical Substances under Chemical Substances Control Law, 1979))
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）