Chemical Name：N-Isopropylaminophosphoric acid ethyl(3-methyl-4-methylthiophenyl)ester, (Fenamiphos)
CAS：22224-92-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	LD50 values are 2.4, 6.0, 6.1, 8.1, 9.6, 17.2 and 19.4 mg/kg (JMPR 929 (1997)), one value corresponds to Category 1 and six values correspond to Category 2. The substance was classified into Category 2 since 6 of 7 LD50 values are in this category.
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	LD50 values are 72, 73, 84, 92, 154 and 500 mg/kg for rats (JMPR 929 (1997)), five values correspond to Category 2 and one value corresponds to Category 3 and the substance was classified into Category 2. LD50 values are 179 and 225 mg/kg for rabbits (JMPR 929 (1997)), the values correspond to Category 2 and 3, respectively and the substance was also classified into Category 2 based on the lower value. Since the categories in both species are same, the substance was classified into Category 2.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a LC50 (4h) value of 0.091 - 0.100 mg/L for rats (JMPR 929 (1997)), the substance was classified into Category 2. Since there is a report of aerosols, the classification criteria for dust was adopted.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on a result of "minimal irritation" and an average PII (primary irritation index of skin: 0.42) following 24-hour application (JMPR 929 (1997)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, results of "not a primary irritant" (JMPR 929 (1997)) and "only slightly irritant" (PATTY (5th, 2001)) are also reported.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Moderate irritation was noted in a rabbit skin irritation test with the substance. Maximum average score within 24-hour post application was 31.3 and all symptoms were resolved within 240-hour in this test (JMPR 929 (1997)). Since the data were considered to correspond to 30 - 80 of AOI (acute ocular irritation index), the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	In a guinea pig maximization test, the positive rate was reported to be 22% (less than 30%) (JMPR 929 (1997)). In another guinea pig maximization test, there is a report that fenamiphos did not induce contact dermatitis or delayed-type allergy (PATTY (5th, 2001)). Based on the data, the substance was classified as "Not classified".
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on a negative result in a mouse dominant lethal test (in vivo heritable germ cell mutagenicity test) (JMPR 300 (1974), PATTY (5th, 2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (NTP DB (access on May. 2009)), a negative CHO cell forward mutation test (PATTY (5th, 2001)), a positive human lymphocyte chromosomal aberration test (PATTY (5th, 2001)) and a negative chromosomal aberration test (PATTY (5th, 2001)).
6	Carcinogenicity	Not classified	-	-	-	-	Based on the classification of "A4" in ACGIH (ACGIH (2001)), the substance was classified as "Not classified". There was no evidence of carcinogenicity in a 2-year feeding test in rats and a 20-month feeding test in mice (PATTY (5th, 2001)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 2-generation and 3-generation oral reproductive tests in rats, there were no adverse effects on reproduction or fetal development (PATTY (5th, 2001), JMPR 929 (1997)). However, in a developmental toxicity test in rabbits by oral administration during the organogenesis period, an increase in the incidence of skeletal malformation (sternal fusion), fetal death and late resorptions were observed at dose levels in which general toxicity such as decreased maternal body weight gain was observed (ACGIH (2006)). Based on the data, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	After oral administration to rats, cholinergic signs such as muscle fasciculations, convulsions, impairment of motor coordination and laboured breathing, were observed with depression of erythrocyte cholinesterase activity at a dose level of 1.5 mg/kg bw (JMPR 929 (1997)). Based on the data, the substance was classified into Category 1 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 3-month feeding tests in rats and dogs, cholinergic signs (muscle fasciculations etc.) were observed at 32 ppm (1.6 mg/kg bw) and 18 ppm (0.45 mg/kg/day), respectively. Plasma and erythrocyte cholinesterase activities were statistically significantly reduced in both species (JMPR 929 (1997)). Since these symptoms were caused by overstimulation of the nerve fiber receptor with cholinesterase inhibition that is characteristic of organophosphorus compounds, the substance was classified into Category 1 (nervous system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 48h-EC50 = 0.0019 mg/L for Crustacea (Daphnia magna) (Hazard Assessment Report (CERI, NITE), 2008).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (BIOWIN).
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.