NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：Allyl alcohol
CAS：107-18-6

Result：


ID:	21B3077
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 2 since flash point 21 degC (closed-cup) (ICSC (2000)) is <23 degC and boiling point 97.4 degC (Lide (88th, 2008)) is >35 degC.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification is not possible since no data are available though there is unsaturated bond in the molecules. The substance is classified into Division 6.1, Subsidiary risk 3, PG I in UNRTDG (UN1098), but not into Division 4.1, however the judgement can not be done from the Precedence of hazards Table.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 378 degC (ICSC (2000)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available. Information is available that the substance is not corrosive to metals (HSDB (2000)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LD50 values of 99 - 105 mg/kg, 70 mg/kg (SIDS (2005)) and 64 mg/kg (ACGIH (7th, 2001)) for rats, the substance was classified into Category 3. In EU classification, the substance is classified into T; R23/24/25 (EU-Annex1 (access on May 2009)).
1	Acute toxicity （Dermal）	Category 1		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LD50 values of 89 mg/kg (SIDS (2005)) and 45 mg/kg (DFGOT vol. 15 (2001)) for rabbits, the substance was classified into Category 1. As relevant information, In the substance is classified into T; R24 in EU classification (EU-Annex I (access on May 2009)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LC50 (4h) values of 127 - 139 ppm (SIDS (2005)), 165 ppm (PATTY (5th, 2001) and 165 ppm (DFGOT vol. 15 (2001)) for rats, the substance was classified into Category 2. In EU classification, the substance is classified into T; R23 (EU-Annex I (access on May 2009)). Since the test was conducted at lower than 90% of saturated vapour pressure concentrations of the substance (34356 ppm), the classification criteria for gas (ppm) was adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Although there is a result of "slightly irritating" or "not irritating" following an occlusive application of the undiluted substance to rabbits for 24-hour (SIDS (2005)), it is reported that the substance is irritating to the human skin and causes local convulsion and pain through muscular effects (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). The substance is classified into Xi; R36/37/38 in EU classification (EU-Annex I (access on May 2009)). Based on these information, the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	In a rabbit test (Directive 84/449/EEC, B.5), mean results at 24, 48 and 72-hour after application were 2.89 for erythema, 1.23 for chemosis, 2.09 for corneal opacity and the classification was "irritating" (SIDS (2005)). Similar irritancy and recovery properties are reported in two other rabbit tests (one test was according to OECD TG405) (SIDS (2005)). There is a result of "mild to moderate irritating" in a human inhalation exposure test (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Accidental cases of corneal burn (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)) and transient blindness (ACGIH (7th, 2001)) are reported to be reversible. The substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	In a guinea pig maximization test (OECD TG406), positive reaction was not observed (positive rate: 0/20), and the substance was determined to be a non skin sensitizer (SIDS (2005)). The substance was classified as "Not classified".
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results in a dominant lethal test by oral administration to rats (in vivo heritable germ cell mutagenicity test), a bone marrow micronucleus test by intraperitoneal administration to rats and a peripheral blood micronucleus test by oral administration to mice (in vivo somatic cell mutagenicity tests) (SIDS (2005), NTP DB (access on May. 2009)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative in almost all Ames tests (positive results reported in TA100 strain) (NTP DB (access on May. 2009), Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)) and positive results in mouse lymphoma test and Chinese hamster V9 cell gene mutation tests (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)).
6	Carcinogenicity	Not classified	-	-	-	-	Based on the classifications of "A4" in ACGIH (ACGIH (2001)), the substance was classified as "Not classified". In a carcinogenicity test in rats administered via drinking water for 106 weeks, followed by observation until natural death, there was no clear evidence of carcinogenicity, but there was equivocal evidence of carcinogenicity in the liver of female rats (SIDS (2005)).
7	Reproductive toxicity	Not classified	-	-	-	-	In a rat reproduction/developmental toxicity screening test (OECD TG421), toxic symptoms in parent animals, an extension of oestrous cycle length in females, a decrease in viability index on day 4 and total litter loss (from one dam) were observed in the 40 mg/kg bw/day group. There were no adverse effects on the other sexual function or reproductive parameters, and external examination of offspring revealed no abnormalities (SIDS (2005)). The result was not used as the basis of classification since there is a report that adverse effects on offspring may be influenced by parental toxicity. In a prenatal developmental test in rats administered by gavage on gestation days 6 - 19 (OECD TG414), an increased frequency of total litter loss was observed at 35 and 50 mg/kg bw/day dose levels but there were no effects on intrauterine growth or survival in the fetuses from dams that survived to necropsy and there were no increases in malformation rates or incidence of variations (SIDS (2005)). The total litter loss was observed at middle and high dose levels at which serious general toxicity including maternal deaths was observed (SIDS (2005)). Because of the serious general toxicity observed in the middle and high dose levels of the prenatal development test, the results of that test not used as the basis of classification. Based on the available data, the substance was classified as "Not classified" since there were no directly related adverse effects on parental sexual function and fertility and fetal development.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, lung, liver, kidney), Category 3 (respiratory tract irritation)		Danger Warning	H370: Causes damage to organs (central nervous system, lung, liver, kidney) H335: May cause respiratory irritation (respiratory tract irritation)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	In rats, apathy, anxiety and coma were observed at dose levels of 75 - 130 mg/kg after an oral administration (SIDS (2005)). Coma, tremor and convulsion were observed at dose levels of 0.095 - 5.450 mg/L after inhalation exposure (ACGIH (2001)). One of the main symptoms of exposure is central nervous system effects (DFGOT vol. 15 (2001)). Based on the data, the substance was classified into Category 1 (central nervous system). In addition, from the pathological findings in above rat tests, the substance was classified into Category 1 (lung) based on reports of edema and congestion of the lung, Category 1 (liver) based on reports of discoloration and necrosis of the liver, Category 1 (kidney) based on reports of swollen and discolored kidney, heme casts and cloudy swelling in the kidney. In other oral tests with rats, extensive periportal necrosis was observed at a dose of 30 mg/kg, and hepatocyte necrosis with increased ALP activity and lipid peroxidation was noted at a dose of 85.4 mg/kg (SIDS (2005)), which indicated that the liver is a target organ. In a vapour exposure test with human volunteers, irritation to nasal mucosa was indicated at 30 mg/m3 (SIDS (2005)). In an inhalation test with mice, a transient decrease in respiratory rate due to sensory irritation was observed (SIDS (2005)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (kidney, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 13 to 14-week oral tests with rats, necrosis with regeneration in the liver was noted at 1000 ppm (67.4 - 72 mg/kg/day) (SIDS (2005)), and periportal hepatocellular hypertrophy was noted at 25 mg/kg/day (NTP TOX 48 (2006)). In a 42-day oral test with rats, necrosis, fibrosis, and proliferation of bile duct in the liver were observed at 40 mg/kg bw/day (90-day equivalence: 18.7 mg/kg/day) (SIDS (2005)). In a 14-week oral test with mice, portal cytoplasmic vacuolization was noted at 25 mg/kg/day and higher dose levels (NTP TOX 48 (2006)). In a 5-week inhalation exposure test in rats, enlargement of venous sinus, and cloudy swelling and focal necrosis in the liver were found at 16.6 mg/m3 (90-day equivalent: 0.007 mg/L) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Since effects were noted at dose levels within the guidance value range for Category 1 following inhalation, the substance was classified into Category 1 (liver). In a 14-week drinking water test in rats, adverse effects in kidney tissue were observed at 100 ppm (6.9 - 8.3 mg/kg/day) and higher dose levels (SIDS (2005)). Proliferation of interstitial tissue, necrosis of tubular epithelium and nephritic change of glomeruli in the kidney were observed at 16.6 mg/m3 (90-day equivalent: 0.007 mg/L) following 5-weeks of inhalation exposure to rats (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Based on the data, the substance was classified into Category 1 (kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	Although the substance is a mixture of n-primary alcohols with a composition of at least 3 carbon atoms but not more than 13 (correspond to Category 2 in GHS classification), classification was not possible due to lack of sufficient data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 96h-LC50 = 320 microg/L for fish (Fathead minnow) (Initial Environmental Risk Assessment of Chemical Substances (Ministry of the Environment), Vol. 3, 2004, etc).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Classified into Not classified since it is rapidly degradable (BOD degradation rate: 86% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1976)) and low bioaccumulative potential is estimated (log Kow = 0.17 (PHYSPROP Database, 2009)).
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）