GHS Classification Result （Revision of the past classification result）

Chemical Name：n-Propyl alcohol
CAS：71-23-8

Result：
ID: 21B3052
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 since flash point 15 degC (ICSC (J) (1999)) is <23 degC and boiling point is 97 degC, further the substance is classified into Class 3, PG II in UNRTDG (UN1274).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 371 degC (ICSC (J) (1999)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 values are 1900 mg/kg (ACGIH (2004)), 1870 mg/kg (PATTY (4th, 1994)), 5400 mg/kg (PATTY (4th, 1994)), 6500 mg/kg (PATTY (4th, 1994), EHC 102 (1990)) and 2200 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 6, 2008)) for rats, and two values correspond to Category 4 and three values correspond to "Not classified" in JIS Classification. The substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification) since 3 of 5 LD50 values are in this category.
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of 6700 mg/kg (PATTY (5th, 2001), ACGIH (2007)), 4060 mg/kg (ACGIH (2007)), 4000 mg/kg (PATTY (5th, 2001)) and 4050 mg/kg (EHC 102 (1990)) for rabbits, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, 2/6 rats died during 4-hour exposures at 4000 ppm (9.84 mg/L) (EHC 102 (1990), PATTY (5th, 2001)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on results of "very slightly irritating" and "no irritating" in rabbit tests (PATTY (5th, 2001), IUCLID (2000)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is a report that when the substance was applied to the eyes of rabbits, severe conjunctivitis, iritis, corneal opacities and ulcerations were observed (ACGIH (2004), PATTY (5th, 2001)). The substance is classified into Xi; R41 in EU classification. Based on these information, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - There is a result of "not sensitizing" in a guinea pig maximization test. However, the information is reported in a document in List 2 and lacks detailed data (IUCLID (2000)). There is also a result of "not sensitizing" in a mouse ear-swelling test. However, the method employed in the conduct of the test is not recommended for classification (EHC 102 (1990)). Classification was not possible due to lack of sufficient data. As relevant information, in humans, there is a case report of positive result in a patch test (EHC 102 (1990)) but there is a result of "not sensitizing" in another patch test (IUCLID (2000)).
5 Germ cell mutagenicity Classification not possible - - - - Although there is a report that structural chromosomal aberration and aneuploidy were observed in a rat bone marrow chromosomal aberration test by oral administration (in vivo somatic cell mutagenicity test) (BUA Report No. 190 (1998)), the result was not used as the basis for classification due to imperfection of the evidence and methodology shortcomings. As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test, a negative micronucleus test and a negative sister chromatid exchange test using hamster culture cells (ACGIH (2007), PATTY (5th, 2001), EHC 102 (1990)).
6 Carcinogenicity Not classified - - - - Based on the classification of "A4" in ACGIH (2007), the substance was classified as "Not classified". In two animal tests, increased incidences of liver sarcomas were observed but the substance was not classified into "A3" based these test results because of lack of adequate details regarding experimental design and the use of a single dose in each test (ACGIH (2007)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In an inhalation test, male rats exposed to the substance for 6 weeks were mated to unexposed females. The female rats then exposed to the substance from days 1 to 19 of gestation. A marked reduction in male fertility (ACGIH (2007)) and a remarkable increase in resorptions (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008), PATTY (5th, 2001)) were observed at dose levels in which maternal general toxicity was noted, as evidenced by reduced body weight gain and reduced food consumption. Based on the data, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Deep narcosis was observed in mice following inhalation exposure of the substance (EHC 102 (1990), PATTY (5th, 2001)). The ED50 values for narcosis in rabbits is reported to be 1440 mg/kg bw orally (EHC 102 (1990)). Based on the data, the substance was classified into Category 3 (narcotic effects). Since the threshold value for irritation (eyes and nose) in humans is reported to be 4,000 - 16,000 ppm, the substance was classified into Category 3 (respiratory tract irritation). The principal toxic effect following a single exposure is depression of the central nervous system (EHC 102 (1990)). In the only fatal poisoning case reported, it was recorded that a woman was found unconscious and died 4 - 5-hour after ingestion of approximately a half a liter of the compound as a solvent in a cosmetic preparation (EHC 102 (1990)). No other adverse effects were reported.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data. In 13-week and 1.5-year oral tests in rats, fatty degeneration, necrosis and fibrosis in the liver and hyperplasia of hematopoietic parenchyma in the bone marrow were reported (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008), EHC 102 (1990), BUA Report No. 190 (1998)). Since the effects were observed at dose levels exceeding the guidance value range, the information was not used as the basis of classification.
10 Aspiration hazard Classification not possible - - - - Since the substance is a mixture of n-primary alcohols with a composition of at least 3 carbon atoms but not more than 13, the substance corresponds to Category 2 in GHS classification. However, classification was not possible due to lack of data corresponding to Category 1 and according to guidance of JIS Classification in which category 2 is not set.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 48h-LC50 = 3025 mg/L for Crustacea (Daphnid) (EHC 102, 1990, etc).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 1000000 mg/L (PHYSPROP Database, 2009).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information